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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 1
1997 1
1999 2
2002 2
2004 2
2006 1
2008 1
2009 1
2010 3
2011 2
2012 6
2013 8
2014 13
2015 25
2016 27
2017 42
2018 34
2019 39
2020 38
2021 58
2022 69
2023 65
2024 31

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421 results

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Page 1
Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma.
Zhang X, Yu K, Ma L, Qian Z, Tian X, Miao Y, Niu Y, Xu X, Guo S, Yang Y, Wang Z, Xue X, Gu C, Fang W, Sun J, Yu Y, Wang J. Zhang X, et al. Theranostics. 2021 Mar 24;11(12):5650-5674. doi: 10.7150/thno.55482. eCollection 2021. Theranostics. 2021. PMID: 33897873 Free PMC article.
Results: The accumulation of endogenous glutamate following system X(C)(-) inhibition has been shown to determine ferroptosis sensitivity by suppressing YAP in LUAD cells. ...Conclusions: Endogenous glutamate is critical for ferroptosis sensitivity following the inh …
Results: The accumulation of endogenous glutamate following system X(C)(-) inhibition has been shown to determine ferroptosis …
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination.
Yu J, Green MD, Li S, Sun Y, Journey SN, Choi JE, Rizvi SM, Qin A, Waninger JJ, Lang X, Chopra Z, El Naqa I, Zhou J, Bian Y, Jiang L, Tezel A, Skvarce J, Achar RK, Sitto M, Rosen BS, Su F, Narayanan SP, Cao X, Wei S, Szeliga W, Vatan L, Mayo C, Morgan MA, Schonewolf CA, Cuneo K, Kryczek I, Ma VT, Lao CD, Lawrence TS, Ramnath N, Wen F, Chinnaiyan AM, Cieslik M, Alva A, Zou W. Yu J, et al. Nat Med. 2021 Jan;27(1):152-164. doi: 10.1038/s41591-020-1131-x. Epub 2021 Jan 4. Nat Med. 2021. PMID: 33398162 Free PMC article.
Mesenchymal stem cells protect against ferroptosis via exosome-mediated stabilization of SLC7A11 in acute liver injury.
Lin F, Chen W, Zhou J, Zhu J, Yao Q, Feng B, Feng X, Shi X, Pan Q, Yu J, Li L, Cao H. Lin F, et al. Cell Death Dis. 2022 Mar 26;13(3):271. doi: 10.1038/s41419-022-04708-w. Cell Death Dis. 2022. PMID: 35347117 Free PMC article.
The aberrant expression of ubiquitinated SLC7A11 triggered by CCl(4) could be rescued with OTUB1-mediated deubiquitination, thus strengthening SLC7A11 stability and thereby leading to the activation of system X(C)(-) to prevent CCl(4)-induced hepatocyte ferroptosis. …
The aberrant expression of ubiquitinated SLC7A11 triggered by CCl(4) could be rescued with OTUB1-mediated deubiquitination, thus strengtheni …
The m6A reader YTHDC2 inhibits lung adenocarcinoma tumorigenesis by suppressing SLC7A11-dependent antioxidant function.
Ma L, Chen T, Zhang X, Miao Y, Tian X, Yu K, Xu X, Niu Y, Guo S, Zhang C, Qiu S, Qiao Y, Fang W, Du L, Yu Y, Wang J. Ma L, et al. Redox Biol. 2021 Jan;38:101801. doi: 10.1016/j.redox.2020.101801. Epub 2020 Nov 18. Redox Biol. 2021. PMID: 33232910 Free PMC article.
Furthermore, solute carrier 7A11 (SLC7A11), the catalytic subunit of system X(C)(-), was identified to be the direct target of YTHDC2. YTHDC2 destabilized SLC7A11 mRNA in an m(6)A-dependent manner because YTHDC2 preferentially bound to m(6)A-modified SLC7A11 mRNA an …
Furthermore, solute carrier 7A11 (SLC7A11), the catalytic subunit of system X(C)(-), was identified to be the direct target of …
Exosomal miR-146a-5p and miR-155-5p promote CXCL12/CXCR7-induced metastasis of colorectal cancer by crosstalk with cancer-associated fibroblasts.
Wang D, Wang X, Song Y, Si M, Sun Y, Liu X, Cui S, Qu X, Yu X. Wang D, et al. Cell Death Dis. 2022 Apr 20;13(4):380. doi: 10.1038/s41419-022-04825-6. Cell Death Dis. 2022. PMID: 35443745 Free PMC article.
C-X-C motif chemokine receptor 7 (CXCR7) is a newly discovered atypical chemokine receptor that binds to C-X-C motif chemokine ligand 12 (CXCL12) with higher affinity than CXCR4 and is associated with the metastasis of colorectal cancer (CRC). ...
C-X-C motif chemokine receptor 7 (CXCR7) is a newly discovered atypical chemokine receptor that binds to C-X-C m …
Tirofiban for Stroke without Large or Medium-Sized Vessel Occlusion.
Zi W, Song J, Kong W, Huang J, Guo C, He W, Yu Y, Zhang B, Geng W, Tan X, Tian Y, Liu Z, Cao M, Cheng D, Li B, Huang W, Liu J, Wang P, Yu Z, Liang H, Yang S, Tang M, Liu W, Huang X, Liu S, Tang Y, Wu Y, Yao L, Shi Z, He P, Zhao H, Chen Z, Luo J, Wan Y, Shi Q, Wang M, Yang D, Chen X, Huang F, Mu J, Li H, Li Z, Zheng J, Xie S, Cai T, Peng Y, Xie W, Qiu Z, Liu C, Yue C, Li L, Tian Y, Yang D, Miao J, Yang J, Hu J, Nogueira RG, Wang D, Saver JL, Li F, Yang Q; RESCUE BT2 Investigators. Zi W, et al. N Engl J Med. 2023 Jun 1;388(22):2025-2036. doi: 10.1056/NEJMoa2214299. N Engl J Med. 2023. PMID: 37256974 Clinical Trial.
Modulation of the proteostasis network promotes tumor resistance to oncogenic KRAS inhibitors.
Lv X, Lu X, Cao J, Luo Q, Ding Y, Peng F, Pataer A, Lu D, Han D, Malmberg E, Chan DW, Wang X, Savage SR, Mao S, Yu J, Peng F, Yan L, Meng H, Maneix L, Han Y, Chen Y, Yao W, Chang EC, Catic A, Lin X, Miles G, Huang P, Sun Z, Burt B, Wang H, Wang J, Yao QC, Zhang B, Roth JA, O'Malley BW, Ellis MJ, Rimawi MF, Ying H, Chen X. Lv X, et al. Science. 2023 Sep 8;381(6662):eabn4180. doi: 10.1126/science.abn4180. Epub 2023 Sep 8. Science. 2023. PMID: 37676964 Free PMC article.
In vivo self-assembled small RNAs as a new generation of RNAi therapeutics.
Fu Z, Zhang X, Zhou X, Ur-Rehman U, Yu M, Liang H, Guo H, Guo X, Kong Y, Su Y, Ye Y, Hu X, Cheng W, Wu J, Wang Y, Gu Y, Lu SF, Wu D, Zen K, Li J, Yan C, Zhang CY, Chen X. Fu Z, et al. Cell Res. 2021 Jun;31(6):631-648. doi: 10.1038/s41422-021-00491-z. Epub 2021 Mar 29. Cell Res. 2021. PMID: 33782530 Free PMC article.
CXCR4-dependent macrophage-to-fibroblast signaling contributes to cardiac diastolic dysfunction in heart failure with preserved ejection fraction.
Zhang N, Ma Q, You Y, Xia X, Xie C, Huang Y, Wang Z, Ye F, Yu Z, Xie X. Zhang N, et al. Int J Biol Sci. 2022 Jan 9;18(3):1271-1287. doi: 10.7150/ijbs.65802. eCollection 2022. Int J Biol Sci. 2022. PMID: 35173552 Free PMC article.
Monocyte/macrophage accumulation and inflammation are crucial elements in the pathogenesis of hypertension-induced cardiac remodeling. The C-X-C chemokine receptor 4 (CXCR4) is a critical regulator of the macrophage-mediated immune response. ...Furthermore, transcri …
Monocyte/macrophage accumulation and inflammation are crucial elements in the pathogenesis of hypertension-induced cardiac remodeling. The C …
421 results