Tacrolimus pharmacokinetics in pediatric nephrotic syndrome: A combination of population pharmacokinetic modelling and machine learning approaches to improve individual prediction.
Huang Q, Lin X, Wang Y, Chen X, Zheng W, Zhong X, Shang D, Huang M, Gao X, Deng H, Li J, Zeng F, Mo X.
Huang Q, et al.
Front Pharmacol. 2022 Nov 15;13:942129. doi: 10.3389/fphar.2022.942129. eCollection 2022.
Front Pharmacol. 2022.
PMID: 36457704
Free PMC article.
Results: A one-compartment model of first-order absorption and elimination adequately described the pharmacokinetics of TAC. Age, co-administration of Wuzhi capsules, CYP3A5 *3/*3 genotype and CTLA4 rs4553808 genotype were significantly affecting the clearance of TAC. ...
Results: A one-compartment model of first-order absorption and elimination adequately described the pharmacokinetics of TAC. Age, co-adminis …