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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1975 1
1976 1
1977 4
1978 1
1979 1
1980 1
1981 2
1983 5
1984 1
1986 3
1987 2
1988 1
1990 3
1991 2
1993 3
1994 7
1995 3
1996 3
1997 3
1998 3
1999 6
2000 9
2001 12
2002 9
2003 10
2004 9
2005 9
2006 19
2007 13
2008 8
2009 32
2010 16
2011 26
2012 23
2013 23
2014 37
2015 46
2016 51
2017 58
2018 61
2019 63
2020 68
2021 82
2022 93
2023 70
2024 27

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Search Results

834 results

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Page 1
CD8+ T cell differentiation and dysfunction in cancer.
Philip M, Schietinger A. Philip M, et al. Nat Rev Immunol. 2022 Apr;22(4):209-223. doi: 10.1038/s41577-021-00574-3. Epub 2021 Jul 12. Nat Rev Immunol. 2022. PMID: 34253904 Free PMC article. Review.
We highlight similarities and differences between T cell dysfunction and other hyporesponsive T cell states and discuss the spatio-temporal factors contributing to T cell state heterogeneity in tumours. An important challenge is predicting which patients will respond to im …
We highlight similarities and differences between T cell dysfunction and other hyporesponsive T cell states and discuss the spatio-temporal …
Sickle cell disease: progress towards combination drug therapy.
Pace BS, Starlard-Davenport A, Kutlar A. Pace BS, et al. Br J Haematol. 2021 Jul;194(2):240-251. doi: 10.1111/bjh.17312. Epub 2021 Jan 20. Br J Haematol. 2021. PMID: 33471938 Free PMC article. Review.
John Herrick described the first clinical case of sickle cell anaemia (SCA) in the United States in 1910. Subsequently, four decades later, Ingram and colleagues characterized the A to T substitution in DNA producing the GAG to GTG codon and replacement of glutamic acid wi …
John Herrick described the first clinical case of sickle cell anaemia (SCA) in the United States in 1910. Subsequently, four decades later, …
Novel Therapies for High-Risk Non-Muscle Invasive Bladder Cancer.
Al Hussein Al Awamlh B, Chang SS. Al Hussein Al Awamlh B, et al. Curr Oncol Rep. 2023 Feb;25(2):83-91. doi: 10.1007/s11912-022-01350-9. Epub 2022 Dec 26. Curr Oncol Rep. 2023. PMID: 36571706 Free PMC article. Review.
As the landscape of managing BCG-unresponsive disease evolves, clinical trials will explore future options and determine effective alternatives....
As the landscape of managing BCG-unresponsive disease evolves, clinical trials will explore future options and determine effective al …
Cutaneous adverse events caused by immune checkpoint inhibitors.
Quach HT, Johnson DB, LeBoeuf NR, Zwerner JP, Dewan AK. Quach HT, et al. J Am Acad Dermatol. 2021 Oct;85(4):956-966. doi: 10.1016/j.jaad.2020.09.054. Epub 2021 Jul 28. J Am Acad Dermatol. 2021. PMID: 34332798 Review.
Cutaneous toxicities are common immune-related adverse events and patients will often be referred to dermatologists for evaluation. OBSERVATIONS: Cutaneous adverse events to ICIs can have a variety of clinical presentations. ...CONCLUSIONS AND RELEVANCE: As they become mor …
Cutaneous toxicities are common immune-related adverse events and patients will often be referred to dermatologists for evaluation. O …
Oncogenic functions and therapeutic targeting of EphA2 in cancer.
Wilson K, Shiuan E, Brantley-Sieders DM. Wilson K, et al. Oncogene. 2021 Apr;40(14):2483-2495. doi: 10.1038/s41388-021-01714-8. Epub 2021 Mar 8. Oncogene. 2021. PMID: 33686241 Free PMC article. Review.
Other small molecules, therapeutic targeting antibodies, and peptide-drug conjugates are being tested, and more recently, approaches harnessing antitumor immunity against EphA2-expressing cancer cells have emerged as a promising strategy. This review will summarize preclin …
Other small molecules, therapeutic targeting antibodies, and peptide-drug conjugates are being tested, and more recently, approaches harness …
Endogenous opioid peptides in the descending pain modulatory circuit.
Bagley EE, Ingram SL. Bagley EE, et al. Neuropharmacology. 2020 Aug 15;173:108131. doi: 10.1016/j.neuropharm.2020.108131. Epub 2020 May 15. Neuropharmacology. 2020. PMID: 32422213 Free PMC article. Review.
One of the key functions of endogenous opioid peptides is to modulate our responses to pain. This review will focus on the descending pain modulatory circuit which consists of the ventrolateral periaqueductal gray (PAG) projections to the rostral ventromedial medulla (RVM) …
One of the key functions of endogenous opioid peptides is to modulate our responses to pain. This review will focus on the descending …
Conceptualizing Post Intensive Care Syndrome in Children-The PICS-p Framework.
Manning JC, Pinto NP, Rennick JE, Colville G, Curley MAQ. Manning JC, et al. Pediatr Crit Care Med. 2018 Apr;19(4):298-300. doi: 10.1097/PCC.0000000000001476. Pediatr Crit Care Med. 2018. PMID: 29406379 Review.
DATA SYNTHESIS: The Post Intensive Care Syndrome in pediatrics (PICS-p) framework highlights the importance of baseline status, organ system maturation, psychosocial development, the interdependence of family, and trajectories of health recovery that can potentially impact a chil …
DATA SYNTHESIS: The Post Intensive Care Syndrome in pediatrics (PICS-p) framework highlights the importance of baseline status, organ system …
Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.
Williams JT, Ingram SL, Henderson G, Chavkin C, von Zastrow M, Schulz S, Koch T, Evans CJ, Christie MJ. Williams JT, et al. Pharmacol Rev. 2013 Jan 15;65(1):223-54. doi: 10.1124/pr.112.005942. Print 2013 Jan. Pharmacol Rev. 2013. PMID: 23321159 Free PMC article. Review.
Further elucidation of the cellular mechanisms that are regulated by opioids will be necessary for the successful development of MOR-based approaches to new pain therapeutics that limit the development of tolerance....
Further elucidation of the cellular mechanisms that are regulated by opioids will be necessary for the successful development of MOR- …
The EXTENSIN enigma.
Moussu S, Ingram G. Moussu S, et al. Cell Surf. 2023 Jan 6;9:100094. doi: 10.1016/j.tcsw.2023.100094. eCollection 2023 Dec. Cell Surf. 2023. PMID: 36659959 Free PMC article. Review.
However, like many other classes of cell wall proteins, EXTs are biochemically complex, highly diverse, and are encoded by multiple genes, making in-depth functional characterization a challenging undertaking. Here we will provide an overview of current knowledge of the bi …
However, like many other classes of cell wall proteins, EXTs are biochemically complex, highly diverse, and are encoded by multiple genes, m …
834 results