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Systematic LC/MS/MS Investigations for the IND-Enabling Extended Characterization of Antibody-Drug Conjugate Modifications.
Antibodies (Basel). 2018 Nov 16;7(4):40. doi: 10.3390/antib7040040.
Antibodies (Basel). 2018.
PMID: 31544890
Free PMC article.
A simple LC/MRM-MS-based method to quantify free linker-payload in antibody-drug conjugate preparations.
Zmolek W, Bañas S, Barfield RM, Rabuka D, Drake PM.
Zmolek W, et al.
J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 1;1032:144-148. doi: 10.1016/j.jchromb.2016.05.055. Epub 2016 Jun 1.
J Chromatogr B Analyt Technol Biomed Life Sci. 2016.
PMID: 27311685
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CAT-02-106, a Site-Specifically Conjugated Anti-CD22 Antibody Bearing an MDR1-Resistant Maytansine Payload Yields Excellent Efficacy and Safety in Preclinical Models.
Drake PM, Carlson A, McFarland JM, Bañas S, Barfield RM, Zmolek W, Kim YC, Huang BCB, Kudirka R, Rabuka D.
Drake PM, et al. Among authors: zmolek w.
Mol Cancer Ther. 2018 Jan;17(1):161-168. doi: 10.1158/1535-7163.MCT-17-0776. Epub 2017 Nov 15.
Mol Cancer Ther. 2018.
PMID: 29142069
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