Acylated Aminooligosaccharides with Inhibitory Effects against α-Amylase from Streptomyces sp. HO1518

Mar Drugs. 2018 Oct 23;16(11):403. doi: 10.3390/md16110403.

Abstract

Five new acylated aminooligosaccharides (1⁻5), together with one known related analogue (6), were isolated from Streptomyces sp. HO1518. Their structure was identified by extensive spectroscopic analysis, including 1D and 2D NMR data and high resolution electrospray ionization mass spectrometry (HRESIMS), and by comparison with those reported in the literature. All of the new compounds showed more promising porcine pancreatic α-amylase (PPA) inhibitory activities than the clinical drug acarbose, indicating them as potential pharmaceutical drug leads toward type II diabetes.

Keywords: Streptomyces sp. HO1518; acylated aminooligosaccharides; porcine pancreatic α-amylase (PPA) inhibitor.

MeSH terms

  • Animals
  • Carbohydrate Sequence
  • Cell Proliferation / drug effects
  • Glycoside Hydrolase Inhibitors / chemistry*
  • Glycoside Hydrolase Inhibitors / isolation & purification
  • Glycoside Hydrolase Inhibitors / pharmacology*
  • Oligosaccharides / chemistry*
  • Oligosaccharides / isolation & purification
  • Oligosaccharides / pharmacology*
  • Pancreatic alpha-Amylases / antagonists & inhibitors*
  • Streptomyces / chemistry*
  • Swine

Substances

  • Glycoside Hydrolase Inhibitors
  • Oligosaccharides
  • Pancreatic alpha-Amylases