Synthesis and characterisation of macrocyclic diamino chiral crown ethers

Waldo H Correa; Janet L Scott

doi:10.3390/90600513

Synthesis and characterisation of macrocyclic diamino chiral crown ethers

Molecules. 2004 May 31;9(6):513-9. doi: 10.3390/90600513.

Authors

Waldo H Correa¹, Janet L Scott

Affiliation

¹ Centre for Green Chemistry, Monash University, P.O. Box 23, Victoria, 3800, Australia. waldo.correa@sci.monash.edu.au

Abstract

A benign and efficient synthesis of chiral macrocyclic 'aza-crown' ethers of varying ring size is reported. The synthesis involves a Schiff base condensation of ether linked dialdehydes of varying chain length and (1R,2R)-(-)-1,2-diaminocyclohexane under mild conditions to yield the macrocycles, which are subsequently reduced to yield the diamino analogues.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Crown Ethers / chemical synthesis*
Crown Ethers / chemistry*
Macrocyclic Compounds / chemical synthesis*
Macrocyclic Compounds / chemistry*
Models, Chemical
Molecular Structure
Stereoisomerism

Substances

Crown Ethers
Macrocyclic Compounds