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IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy.
Zhou T, Damsky W, Weizman OE, McGeary MK, Hartmann KP, Rosen CE, Fischer S, Jackson R, Flavell RA, Wang J, Sanmamed MF, Bosenberg MW, Ring AM. Zhou T, et al. Nature. 2020 Jul;583(7817):609-614. doi: 10.1038/s41586-020-2422-6. Epub 2020 Jun 24. Nature. 2020. PMID: 32581358 Free PMC article.
Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis.
Damsky W, Wang A, Kim DJ, Young BD, Singh K, Murphy MJ, Daccache J, Clark A, Ayasun R, Ryu C, McGeary MK, Odell ID, Fazzone-Chettiar R, Pucar D, Homer R, Gulati M, Miller EJ, Bosenberg M, Flavell RA, King B. Damsky W, et al. Nat Commun. 2022 Jun 6;13(1):3140. doi: 10.1038/s41467-022-30615-x. Nat Commun. 2022. PMID: 35668129 Free PMC article. Clinical Trial.
Interspecies commensal interactions have nonlinear impacts on host immunity.
Rice TA, Bielecka AA, Nguyen MT, Rosen CE, Song D, Sonnert ND, Yang Y, Cao Y, Khetrapal V, Catanzaro JR, Martin AL, Rashed SA, Leopold SR, Hao L, Yu X, van Dijk D, Ring AM, Flavell RA, de Zoete MR, Palm NW. Rice TA, et al. Cell Host Microbe. 2022 Jul 13;30(7):988-1002.e6. doi: 10.1016/j.chom.2022.05.004. Epub 2022 May 30. Cell Host Microbe. 2022. PMID: 35640610 Free PMC article.
Immunoglobulin A Targets a Unique Subset of the Microbiota in Inflammatory Bowel Disease.
Shapiro JM, de Zoete MR, Palm NW, Laenen Y, Bright R, Mallette M, Bu K, Bielecka AA, Xu F, Hurtado-Lorenzo A, Shah SA, Cho JH, LeLeiko NS, Sands BE, Flavell RA, Clemente JC. Shapiro JM, et al. Cell Host Microbe. 2021 Jan 13;29(1):83-93.e3. doi: 10.1016/j.chom.2020.12.003. Epub 2021 Jan 1. Cell Host Microbe. 2021. PMID: 33385335 Free PMC article.
Mutations in synaptojanin disrupt synaptic vesicle recycling.
Harris TW, Hartwieg E, Horvitz HR, Jorgensen EM. Harris TW, et al. J Cell Biol. 2000 Aug 7;150(3):589-600. doi: 10.1083/jcb.150.3.589. J Cell Biol. 2000. PMID: 10931870 Free PMC article.
Thus, these results confirm studies of the mouse synaptojanin 1 mutants, which exhibit defects in the uncoating of synaptic vesicles (Cremona, O., G. Di Paolo, M.R. Wenk, A. Luthi, W.T. Kim, K. Takei, L. Daniell, Y. Nemoto, S.B. Shears, R.A. Flavell, D …
Thus, these results confirm studies of the mouse synaptojanin 1 mutants, which exhibit defects in the uncoating of synaptic vesicles (Cremon …
Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity.
Ring NG, Herndler-Brandstetter D, Weiskopf K, Shan L, Volkmer JP, George BM, Lietzenmayer M, McKenna KM, Naik TJ, McCarty A, Zheng Y, Ring AM, Flavell RA, Weissman IL. Ring NG, et al. Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):E10578-E10585. doi: 10.1073/pnas.1710877114. Epub 2017 Nov 20. Proc Natl Acad Sci U S A. 2017. PMID: 29158380 Free PMC article.
A Deep Learning Model to Predict a Diagnosis of Alzheimer Disease by Using 18F-FDG PET of the Brain.
Ding Y, Sohn JH, Kawczynski MG, Trivedi H, Harnish R, Jenkins NW, Lituiev D, Copeland TP, Aboian MS, Mari Aparici C, Behr SC, Flavell RR, Huang SY, Zalocusky KA, Nardo L, Seo Y, Hawkins RA, Hernandez Pampaloni M, Hadley D, Franc BL. Ding Y, et al. Radiology. 2019 Feb;290(2):456-464. doi: 10.1148/radiol.2018180958. Epub 2018 Nov 6. Radiology. 2019. PMID: 30398430 Free PMC article.
Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues.
Cella M, Gamini R, Sécca C, Collins PL, Zhao S, Peng V, Robinette ML, Schettini J, Zaitsev K, Gordon W, Bando JK, Yomogida K, Cortez V, Fronick C, Fulton R, Lin LL, Gilfillan S, Flavell RA, Shan L, Artyomov MN, Bowman M, Oltz EM, Jelinsky SA, Colonna M. Cella M, et al. Nat Immunol. 2019 Aug;20(8):980-991. doi: 10.1038/s41590-019-0425-y. Epub 2019 Jun 17. Nat Immunol. 2019. PMID: 31209406 Free PMC article.
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