Abstract
The thiophene polyacetylene (E)-1-[5-(hept-5-en-1,3-diynyl)-2-thienyl]ethan-1,2-diol, isolated from the roots of Leuzea carthamoides, showed phototoxic activity in the assay systems of histidine photo-oxidation, Artemia and Tubifex assays. The effects were compared with the standard photosensitizer xanthotoxin.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Artemia / drug effects*
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Ethanol / analogs & derivatives*
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Ethanol / chemistry
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Ethanol / isolation & purification
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Ethanol / toxicity
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Histidine / metabolism
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Lethal Dose 50
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Leuzea / chemistry
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Leuzea / toxicity*
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Methoxsalen / chemistry
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Oligochaeta / drug effects*
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Oxidation-Reduction / drug effects
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Photosensitizing Agents / toxicity*
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Plant Extracts / chemistry
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Plant Extracts / toxicity
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Plant Roots / chemistry
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Thiophenes / chemistry
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Thiophenes / isolation & purification
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Thiophenes / toxicity*
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Ultraviolet Rays
Substances
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Photosensitizing Agents
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Plant Extracts
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Thiophenes
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thiophene polyacetylene (E)-1-(5-(hept-5-en-1,3-diynyl)-2-thienyl)ethan-1,2-diol
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Ethanol
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Histidine
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Methoxsalen