Iodoxybenzoic Acid (IBX) in Organic Synthesis: A Septennial Review

Ravi Varala; Vittal Seema; Mohammed Mujahid Alam; Narsimhaswamy Dubasi; Rama Devi Vummadi

doi:10.2174/0115701794263252230924074035

Iodoxybenzoic Acid (IBX) in Organic Synthesis: A Septennial Review

Curr Org Synth. 2023 Oct 12. doi: 10.2174/0115701794263252230924074035. Online ahead of print.

Authors

Ravi Varala¹, Vittal Seema², Mohammed Mujahid Alam³, Narsimhaswamy Dubasi⁴, Rama Devi Vummadi⁵

Affiliations

¹ Department of R and D, Scrips Pharma, Mallapur, Hyderabad, 500076, Telangana, India.
² Department of Chemistry, RGUKT Basar, Mudhole 504107, Telangana, India.
³ Department of Chemistry, College of Science, King Khalid University, Abha, Saudi Arabia.
⁴ Independent Researcher, 12001, Belcher Rd S, Apt No: N226, Largo, FL 33773, USA.
⁵ Department of Chemistry, Chaitanya Bharathi Institute of Technology (CBIT), Gandipet, Hyderabad-500075, Telangana, India.

PMID: 37861006
DOI: 10.2174/0115701794263252230924074035

Abstract

This study reviews the oxidative applications of 2-iodoxybenzoic acid (IBX) in organic synthesis, focusing on C-H functionalization, hetero-hetero bond formations, ring cleavage reactions, dehydrogenation, heterocyclic ring formations, and some miscellaneous reactions in a comprehensive and critical way. It compiles the literature starting from mid-2015 to date.

Keywords: 2-Iodoxybenzoic acid (IBX); C-H functionalization; critical way; hetero-hetero bond formations; heterocyclic ring formations; organic synthesis; oxidation.