Mean paltelet volume (MPV) the neglected marker of cardiovascular risk and glycosylated hemoglobin in diabetic patient

Introduction: Platelets activation and aggregation play fundamental role in thrombotic events in diabetes. MPV marker of platelet activity determines this cardiovascular risk. So by using simple parameter like MPV we can indirectly assess vascular complication in diabetic patient in periphery.

Aims and objectives: Determining MPV of both T1DM and T2DM with their controls and Relation between HbA1C and MPV in Diabetes Mellitus (DM).

Methodology: This cross-sectional study was conducted in department of medicine, SPMC Bikaner from June 2014 - December 2014, included 100 patients attending medical outdoor and 100 healthy matched controls. Diabetics were divided into 3 GROUPS: HbA1c <6.5%, >6.5 but =< 8% and >8%. Groups were compared with regards to MPV and HbA1c.

Results: MPV was found significantly higher in both T1DM and T2DM compare to control groups (9.606±1.03 and 8.968±1.23 vs 7.85±0.680, p=0.0001). The mean age of diabetic groups were 40.50±5.08 years, 42.26±6.42 years and 44.56±8.25 respectively The mean MPV among diabetic groups were 8.18±0.99, 9.08±1.01, 9.54±1.268 respectively. On statistical comparison the difference was significant (p value-0.001).we also statistically significant difference on comparing HbA1C and MPV in T1DM and T2DM with p=0.006 r- 0.4968 and p=0.013 and r- 0.316 respectively.

Conclusion: This shows that the MPV is significantly higher in patients with high HbA1C levels. Key Words: Glycosylated hemoglobin (HbA1c), Mean platelet volume (MPV).