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Evaluation of mRNA-1273 Covid-19 Vaccine in Children 6 to 11 Years of Age.
Creech CB, Anderson E, Berthaud V, Yildirim I, Atz AM, Melendez Baez I, Finkelstein D, Pickrell P, Kirstein J, Yut C, Blair R, Clifford RA, Dunn M, Campbell JD, Montefiori DC, Tomassini JE, Zhao X, Deng W, Zhou H, Ramirez Schrempp D, Hautzinger K, Girard B, Slobod K, McPhee R, Pajon R, Das R, Miller JM, Schnyder Ghamloush S; KidCOVE Study Group. Creech CB, et al. N Engl J Med. 2022 May 26;386(21):2011-2023. doi: 10.1056/NEJMoa2203315. Epub 2022 May 11. N Engl J Med. 2022. PMID: 35544369 Free PMC article. Clinical Trial.
Induction and transcriptional regulation of the co-inhibitory gene module in T cells.
Chihara N, Madi A, Kondo T, Zhang H, Acharya N, Singer M, Nyman J, Marjanovic ND, Kowalczyk MS, Wang C, Kurtulus S, Law T, Etminan Y, Nevin J, Buckley CD, Burkett PR, Buenrostro JD, Rozenblatt-Rosen O, Anderson AC, Regev A, Kuchroo VK. Chihara N, et al. Nature. 2018 Jun;558(7710):454-459. doi: 10.1038/s41586-018-0206-z. Epub 2018 Jun 13. Nature. 2018. PMID: 29899446 Free PMC article.
Dysregulated expression of co-inhibitory receptors on CD4(+) T cells promotes autoimmunity, whereas sustained overexpression on CD8(+) T cells promotes T cell dysfunction or exhaustion, leading to impaired ability to clear chronic viral infections and diseases such as canc …
Dysregulated expression of co-inhibitory receptors on CD4(+) T cells promotes autoimmunity, whereas sustained overexpression on CD8(+) T cel …
Evaluation of mRNA-1273 Vaccine in Children 6 Months to 5 Years of Age.
Anderson EJ, Creech CB, Berthaud V, Piramzadian A, Johnson KA, Zervos M, Garner F, Griffin C, Palanpurwala K, Turner M, Gerber J, Bennett RL, Ali K, Ampajwala M, Berman G, Nayak J, Chronis C, Rizzardi B, Muller WJ, Smith CA, Fuchs G, Hsia D, Tomassini JE, DeLucia D, Reuter C, Kuter B, Zhao X, Deng W, Zhou H, Ramirez Schrempp D, Hautzinger K, Girard B, Slobod K, McPhee R, Pajon R, Aunins A, Das R, Miller JM, Schnyder Ghamloush S; KidCOVE Study Group. Anderson EJ, et al. N Engl J Med. 2022 Nov 3;387(18):1673-1687. doi: 10.1056/NEJMoa2209367. Epub 2022 Oct 19. N Engl J Med. 2022. PMID: 36260859 Free PMC article. Clinical Trial.
Transcriptomic analysis of pathways associated with ITGAV/alpha(v) integrin-dependent autophagy in human B cells.
Muir V, Sagadiev S, Liu S, Holder U, Armendariz AM, Suchland E, Meitlis I, Camp N, Giltiay N, Tam JM, Garner EC, Wivagg CN, Shows D, James RG, Lacy-Hulbert A, Acharya M. Muir V, et al. Autophagy. 2023 Mar;19(3):926-942. doi: 10.1080/15548627.2022.2113296. Epub 2022 Aug 25. Autophagy. 2023. PMID: 36016494 Free PMC article.
We have previously shown that a form of noncanonical autophagy induced by ITGAV/alpha(v) integrins regulates B cell activation by viral and self-antigens, in mice. ...Integrating data from primary B cells and knockout cells, we found that ITGAV/alpha(v)-depen …
We have previously shown that a form of noncanonical autophagy induced by ITGAV/alpha(v) integrins regulates B cell activation by …
A SARS-CoV-2 targeted siRNA-nanoparticle therapy for COVID-19.
Idris A, Davis A, Supramaniam A, Acharya D, Kelly G, Tayyar Y, West N, Zhang P, McMillan CLD, Soemardy C, Ray R, O'Meally D, Scott TA, McMillan NAJ, Morris KV. Idris A, et al. Mol Ther. 2021 Jul 7;29(7):2219-2226. doi: 10.1016/j.ymthe.2021.05.004. Epub 2021 May 14. Mol Ther. 2021. PMID: 33992805 Free PMC article.
Sequence and functional characterization of a public HIV-specific antibody clonotype.
Murji AA, Raju N, Qin JS, Kaldine H, Janowska K, Fechter EF, Mapengo R, Scheepers C, Setliff I, Acharya P, Morris L, Georgiev IS. Murji AA, et al. iScience. 2021 Dec 3;25(1):103564. doi: 10.1016/j.isci.2021.103564. eCollection 2022 Jan 21. iScience. 2021. PMID: 34984325 Free PMC article.
Our results showed that HIV-1 specificity for the public antibodies studied here, comprising sequences from three individuals, was modulated by the V(H), but not V(L), germline gene. Non-native pairing of public heavy and light chains from different individuals sugg …
Our results showed that HIV-1 specificity for the public antibodies studied here, comprising sequences from three individuals, was modulated …
Longitudinal COVID-19-vaccination-induced antibody responses and Omicron neutralization in patients with lung cancer.
Mack PC, Gomez JE, Rodilla AM, Carreño JM, Hsu CY, Rolfo C, Meshulami N, Moore A, Brody RI, King JC, Treatman J, Lee S, Raskin A, Srivastava K, Gleason CR, de Miguel-Perez D; PARIS/PSP study group; Tcheou J, Bielak D, Acharya R, Gerber DE, Rohs N, Henschke CI, Yankelevitz DF, Simon V, Minna JD, Bunn PA Jr, García-Sastre A, Krammer F, Shyr Y, Hirsch FR. Mack PC, et al. Cancer Cell. 2022 Jun 13;40(6):575-577. doi: 10.1016/j.ccell.2022.04.012. Epub 2022 Apr 20. Cancer Cell. 2022. PMID: 35504289 Free PMC article. No abstract available.
All India Ophthalmological Society - Eye Bank Association of India consensus statement on guidelines for cornea and eyebanking during COVID-19 era.
Sharma N, D'Souza S, Nathawat R, Sinha R, Gokhale NS, Fogla R, Titiyal JS, Maskati QB, Mukherjee G, Sachdev Writing Committee MS; Composition of the All India Ophthalmological Society (AIOS)- Eye Bank Association of India (EBAI) Expert Group for COVID-19 Practice Guidelines for Cornea and Eyebanking includes the Writing Committee (as listed) and the following members - in alphabetical order: Arun Kumar Jain -Post Graduate Institute of Medical Education & Research, Chandigarh; Atul Kapoor - Sightlife, New Delhi; Geetha Iyer- Sankara Nethralaya, Chennai; Hemant Kumar - Abhinav Drishti Eye Hospital, Lucknow; Himanshu Matalia - Narayana Nethralaya, Bangalore; Hitendra Ahooja - Ahooja Eye and Dental Institute, Gurugram; J.K.S. Parihar - Centre for Sight, New Delhi; Jnanankar Medhi - The Retina Centre, Guwahati, Assam; Mandeep Jot Singh - Centre for Sight, New Delhi; Manisha Acharya - Dr. Shroff Charity Eye Hospital, New Delhi; Nilesh Mohan - Regional Institute of Ophthalmology, Igims, Patna; Paras Mehta - Sameep Eye Hospital & Corneal Centre, Vadodara; Prafulla Maharana - Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, Indi… See abstract for full author list ➔ Sharma N, et al. Indian J Ophthalmol. 2020 Jul;68(7):1258-1262. doi: 10.4103/ijo.IJO_1554_20. Indian J Ophthalmol. 2020. PMID: 32587148 Free PMC article. Review.
Development of indigenous IgG ELISA for the detection of anti-SARS-CoV-2 IgG.
Sapkal G, Shete-Aich A, Jain R, Yadav PD, Sarkale P, Lakra R, Baradkar S, Deshpande GR, Mali D, Tilekar BN, Majumdar T, Kaushal H, Gurav Y, Gupta N, Mohandas S, Deshpande K, Kaduskar O, Salve M, Patil S, Gaikwad S, Sugunan AP, Ashok M, Giri S, Shastri J, Abraham P, Gangakhedkar RR; $COVID Support Team: Pawar S., Patshute S., Salve V., Natarajan V., Marwah V., Malhotra B., Jain A., Sathe P., More R., Khedekar R., Suryawanshi D., Kalele K., Kumar A., Upadhyaya C.P., Waghmare A., Gawande P., Gopale S., Acharya M., Holeppanavar M., Thorat S., Chopade G., Vidhate S., Khutwad K., Phagiwala D., Bhanarkar S., Rakhe A., Salvi V., Dhaigude S., Ciyona. Sapkal G, et al. Indian J Med Res. 2020 May;151(5):444-449. doi: 10.4103/ijmr.IJMR_2232_20. Indian J Med Res. 2020. PMID: 32611915 Free PMC article.
Pro-oncogenic, intra host viral quasispecies in Diffuse large B cell lymphoma patients with occult Hepatitis B Virus infection.
Sinha M, Sundar K, Premalata CS, Asati V, Murali A, Bajpai AK, Davuluri S, Acharya KK, Lakshmaiah KC, Babu K G, Jacob LA, Nandan D, Velayutham D, Datta S, Jayshree RS. Sinha M, et al. Sci Rep. 2019 Oct 10;9(1):14516. doi: 10.1038/s41598-019-51157-1. Sci Rep. 2019. PMID: 31601912 Free PMC article.
Sequencing of these gene segments revealed inter-compartment viral variants in 26% of them, each with at least one non-synonymous mutation. ...It would be interesting to further explore if a temporal accumulation of viral variants within a favored niche, like patien …
Sequencing of these gene segments revealed inter-compartment viral variants in 26% of them, each with at least one non-synonymous mut …
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