Impact of UDST: A step forward to end TB

Indian J Tuberc. 2020 Apr;67(2):213-215. doi: 10.1016/j.ijtb.2020.02.009. Epub 2020 Mar 3.

Abstract

Background: India is determined to eliminate TB by 2025 despite being a high burden country. Revised National Tuberculosis Control Programme (RNTCP) is being strengthened with introduction of Universal Drug Susceptibility Testing (UDST) for Rifampicin to achieve the elimination status.

Methodology: We used a before-after comparison of baseline and intervention periods (12 months each) and analyzed data viz CBNAAT performed and case detection for both drug sensitive and drug resistant TB cases.

Results: After implementation of Universal DST, CBNAAT performed raised from 1252 to 3137 (increased by 2.5 times); Rif sensitive cases detected raised from 458 to 1241 (increased by 2.7 times) and Rif resistant cases detected raised from 54 to 82 (increased by 1.5 times) during baseline period (2017) and intervention period (2018).

Conclusion: We conclude that introduction of UDST for Rifampicin in RNTCP has given a significant impact with increased case detection in our study.

Keywords: CBNAAT; RNTCP; UDST.

MeSH terms

  • Antitubercular Agents / therapeutic use*
  • Disease Eradication
  • Drug Resistance, Bacterial / genetics*
  • Humans
  • India
  • Mycobacterium tuberculosis / genetics*
  • Nucleic Acid Amplification Techniques
  • Rifampin / therapeutic use*
  • Tuberculosis, Multidrug-Resistant / diagnosis*
  • Tuberculosis, Multidrug-Resistant / drug therapy
  • Tuberculosis, Multidrug-Resistant / prevention & control

Substances

  • Antitubercular Agents
  • Rifampin