Fatal epithelioid haemangioendothelioma presenting in the lung and liver

Virchows Arch A Pathol Anat Histopathol. 1986;410(1):9-16. doi: 10.1007/BF00710900.

Abstract

Three patients with epithelioid haemangioendothelioma (EHE) are described. Two patients presented with pulmonary infiltrates and one with a hepatic tumour. All had a metastatic disease ending fatally, and all were autopsied. The diagnosis was confirmed either by immunohistological or ultrastructural analysis. All three tumours were cytokeratin-negative and vimentin-positive, while only two contained cells reacting with the antibody of factor VIII-related antigen. Electron microscopy of the third tumour revealed features indicating endothelial differentiation. A short literature review is also presented demonstrating that the outlook of EHE is worse than previously thought.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Aged
  • Aged, 80 and over
  • Female
  • Hemangioendothelioma / secondary*
  • Histocytochemistry
  • Humans
  • Liver / pathology*
  • Liver Neoplasms / secondary*
  • Lung / pathology*
  • Lung Neoplasms / secondary*
  • Male
  • Microscopy, Electron
  • Middle Aged
  • Neoplasm Metastasis