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A new antibiotic kills pathogens without detectable resistance.
Ling LL, Schneider T, Peoples AJ, Spoering AL, Engels I, Conlon BP, Mueller A, Schäberle TF, Hughes DE, Epstein S, Jones M, Lazarides L, Steadman VA, Cohen DR, Felix CR, Fetterman KA, Millett WP, Nitti AG, Zullo AM, Chen C, Lewis K. Ling LL, et al. Among authors: steadman va. Nature. 2015 Jan 22;517(7535):455-9. doi: 10.1038/nature14098. Epub 2015 Jan 7. Nature. 2015. PMID: 25561178 Free PMC article.
Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle.
Mackman RL, Steadman VA, Dean DK, Jansa P, Poullennec KG, Appleby T, Austin C, Blakemore CA, Cai R, Cannizzaro C, Chin G, Chiva JC, Dunbar NA, Fliri H, Highton AJ, Hui H, Ji M, Jin H, Karki K, Keats AJ, Lazarides L, Lee YJ, Liclican A, Mish M, Murray B, Pettit SB, Pyun P, Sangi M, Santos R, Sanvoisin J, Schmitz U, Schrier A, Siegel D, Sperandio D, Stepan G, Tian Y, Watt GM, Yang H, Schultz BE. Mackman RL, et al. Among authors: steadman va. J Med Chem. 2018 Nov 8;61(21):9473-9499. doi: 10.1021/acs.jmedchem.8b00802. Epub 2018 Aug 22. J Med Chem. 2018. PMID: 30074795
Bifunctional crosslinking ligands for transthyretin.
Mangione PP, Deroo S, Ellmerich S, Bellotti V, Kolstoe S, Wood SP, Robinson CV, Smith MD, Tennent GA, Broadbridge RJ, Council CE, Thurston JR, Steadman VA, Vong AK, Swain CJ, Pepys MB, Taylor GW. Mangione PP, et al. Among authors: steadman va. Open Biol. 2015 Sep;5(9):150105. doi: 10.1098/rsob.150105. Open Biol. 2015. PMID: 26400472 Free PMC article.
Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A.
Steadman VA, Pettit SB, Poullennec KG, Lazarides L, Keats AJ, Dean DK, Stanway SJ, Austin CA, Sanvoisin JA, Watt GM, Fliri HG, Liclican AC, Jin D, Wong MH, Leavitt SA, Lee YJ, Tian Y, Frey CR, Appleby TC, Schmitz U, Jansa P, Mackman RL, Schultz BE. Steadman VA, et al. J Med Chem. 2017 Feb 9;60(3):1000-1017. doi: 10.1021/acs.jmedchem.6b01329. Epub 2017 Jan 31. J Med Chem. 2017. PMID: 28075591
Unprecedented Epimerization of an Azithromycin Analogue: Synthesis, Structure and Biological Activity of 2'-Dehydroxy-5″-Epi-Azithromycin.
Kragol G, Steadman VA, Marušić Ištuk Z, Čikoš A, Bosnar M, Jelić D, Ergović G, Trzun M, Bošnjak B, Bokulić A, Padovan J, Glojnarić I, Eraković Haber V. Kragol G, et al. Among authors: steadman va. Molecules. 2022 Feb 3;27(3):1034. doi: 10.3390/molecules27031034. Molecules. 2022. PMID: 35164298 Free PMC article.
Erratum: A new antibiotic kills pathogens without detectable resistance.
Ling LL, Schneider T, Peoples AJ, Spoering AL, Engels I, Conlon BP, Mueller A, Schäberle TF, Hughes DE, Epstein S, Jones M, Lazarides L, Steadman VA, Cohen DR, Felix CR, Fetterman KA, Millett WP, Nitti AG, Zullo AM, Chen C, Lewis K. Ling LL, et al. Among authors: steadman va. Nature. 2015 Apr 16;520(7547):388. doi: 10.1038/nature14303. Epub 2015 Feb 25. Nature. 2015. PMID: 25731174 No abstract available.