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2004 3
2005 1
2015 2
2024 0

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Page 1
A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase.
Atwell S, Adams JM, Badger J, Buchanan MD, Feil IK, Froning KJ, Gao X, Hendle J, Keegan K, Leon BC, Müller-Dieckmann HJ, Nienaber VL, Noland BW, Post K, Rajashankar KR, Ramos A, Russell M, Burley SK, Buchanan SG. Atwell S, et al. Among authors: nienaber vl. J Biol Chem. 2004 Dec 31;279(53):55827-32. doi: 10.1074/jbc.M409792200. Epub 2004 Oct 26. J Biol Chem. 2004. PMID: 15507431 Free article.
Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties.
Bruncko M, McClellan WJ, Wendt MD, Sauer DR, Geyer A, Dalton CR, Kaminski MA, Weitzberg M, Gong J, Dellaria JF, Mantei R, Zhao X, Nienaber VL, Stewart K, Klinghofer V, Bouska J, Rockway TW, Giranda VL. Bruncko M, et al. Among authors: nienaber vl. Bioorg Med Chem Lett. 2005 Jan 3;15(1):93-8. doi: 10.1016/j.bmcl.2004.10.026. Bioorg Med Chem Lett. 2005. PMID: 15582418
Discovery of potent inhibitors of dihydroneopterin aldolase using CrystaLEAD high-throughput X-ray crystallographic screening and structure-directed lead optimization.
Sanders WJ, Nienaber VL, Lerner CG, McCall JO, Merrick SM, Swanson SJ, Harlan JE, Stoll VS, Stamper GF, Betz SF, Condroski KR, Meadows RP, Severin JM, Walter KA, Magdalinos P, Jakob CG, Wagner R, Beutel BA. Sanders WJ, et al. Among authors: nienaber vl. J Med Chem. 2004 Mar 25;47(7):1709-18. doi: 10.1021/jm030497y. J Med Chem. 2004. PMID: 15027862
Identification of novel binding interactions in the development of potent, selective 2-naphthamidine inhibitors of urokinase. Synthesis, structural analysis, and SAR of N-phenyl amide 6-substitution.
Wendt MD, Rockway TW, Geyer A, McClellan W, Weitzberg M, Zhao X, Mantei R, Nienaber VL, Stewart K, Klinghofer V, Giranda VL. Wendt MD, et al. Among authors: nienaber vl. J Med Chem. 2004 Jan 15;47(2):303-24. doi: 10.1021/jm0300072. J Med Chem. 2004. PMID: 14711304