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Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes.
Nortley R, Korte N, Izquierdo P, Hirunpattarasilp C, Mishra A, Jaunmuktane Z, Kyrargyri V, Pfeiffer T, Khennouf L, Madry C, Gong H, Richard-Loendt A, Huang W, Saito T, Saido TC, Brandner S, Sethi H, Attwell D. Nortley R, et al. Among authors: kyrargyri v. Science. 2019 Jul 19;365(6450):eaav9518. doi: 10.1126/science.aav9518. Epub 2019 Jun 20. Science. 2019. PMID: 31221773 Free PMC article.
IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity.
Avloniti M, Evangelidou M, Gomini M, Loupis T, Emmanouil M, Mitropoulou A, Tselios T, Lassmann H, Gruart A, Delgado-García JM, Probert L, Kyrargyri V. Avloniti M, et al. Among authors: kyrargyri v. J Neuroinflammation. 2024 Jan 27;21(1):34. doi: 10.1186/s12974-024-03023-9. J Neuroinflammation. 2024. PMID: 38279130 Free PMC article.