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Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility.
Barc J, Tadros R, Glinge C, Chiang DY, Jouni M, Simonet F, Jurgens SJ, Baudic M, Nicastro M, Potet F, Offerhaus JA, Walsh R, Choi SH, Verkerk AO, Mizusawa Y, Anys S, Minois D, Arnaud M, Duchateau J, Wijeyeratne YD, Muir A, Papadakis M, Castelletti S, Torchio M, Ortuño CG, Lacunza J, Giachino DF, Cerrato N, Martins RP, Campuzano O, Van Dooren S, Thollet A, Kyndt F, Mazzanti A, Clémenty N, Bisson A, Corveleyn A, Stallmeyer B, Dittmann S, Saenen J, Noël A, Honarbakhsh S, Rudic B, Marzak H, Rowe MK, Federspiel C, Le Page S, Placide L, Milhem A, Barajas-Martinez H, Beckmann BM, Krapels IP, Steinfurt J, Winkel BG, Jabbari R, Shoemaker MB, Boukens BJ, Škorić-Milosavljević D, Bikker H, Manevy F, Lichtner P, Ribasés M, Meitinger T, Müller-Nurasyid M; KORA-Study Group; Veldink JH, van den Berg LH, Van Damme P, Cusi D, Lanzani C, Rigade S, Charpentier E, Baron E, Bonnaud S, Lecointe S, Donnart A, Le Marec H, Chatel S, Karakachoff M, Bézieau S, London B, Tfelt-Hansen J, Roden D, Odening KE, Cerrone M, Chinitz LA, Volders PG, van de Berg MP, Laurent G, Faivre L, Antzelevitch C, Kääb S, Arnaout AA, Dupuis JM, Pasquie JL, Billon O, Roberts JD, Jesel L, Borggrefe M, Lambiase PD, Mansourati J, Loe… See abstract for full author list ➔ Barc J, et al. Nat Genet. 2022 Mar;54(3):232-239. doi: 10.1038/s41588-021-01007-6. Epub 2022 Feb 24. Nat Genet. 2022. PMID: 35210625 Free PMC article.
With the exception of SCN5A, encoding the cardiac sodium channel Na(V)1.5, susceptibility genes remain largely unknown. Here we performed a genome-wide association meta-analysis comprising 2,820 unrelated cases with BrS and 10,001 controls, and identified 21 association si …
With the exception of SCN5A, encoding the cardiac sodium channel Na(V)1.5, susceptibility genes remain largely unknown. Here we perfo …
Numerical modelling of the V-J combinations of the T cell receptor TRA/TRD locus.
Thuderoz F, Simonet MA, Hansen O, Pasqual N, Dariz A, Baum TP, Hierle V, Demongeot J, Marche PN, Jouvin-Marche E. Thuderoz F, et al. PLoS Comput Biol. 2010 Feb 19;6(2):e1000682. doi: 10.1371/journal.pcbi.1000682. PLoS Comput Biol. 2010. PMID: 20174554 Free PMC article.
T-Cell antigen Receptor (TR) repertoire is generated through rearrangements of V and J genes encoding alpha and beta chains. The quantification and frequency for every V-J combination during ontogeny and development of the immune system remain to be precisely establ …
T-Cell antigen Receptor (TR) repertoire is generated through rearrangements of V and J genes encoding alpha and beta chains. The quan …
Tomonaga-Luttinger Liquid Spin Dynamics in the Quasi-One-Dimensional Ising-Like Antiferromagnet BaCo_{2}V_{2}O_{8}.
Faure Q, Takayoshi S, Simonet V, Grenier B, Månsson M, White JS, Tucker GS, Rüegg C, Lejay P, Giamarchi T, Petit S. Faure Q, et al. Phys Rev Lett. 2019 Jul 12;123(2):027204. doi: 10.1103/PhysRevLett.123.027204. Phys Rev Lett. 2019. PMID: 31386519
Combining inelastic neutron scattering and numerical simulations, we study the quasi-one-dimensional Ising anisotropic quantum antiferromagnet BaCo_{2}V_{2}O_{8} in a longitudinal magnetic field. This material shows a quantum phase transition from a Neel ordered phase at z …
Combining inelastic neutron scattering and numerical simulations, we study the quasi-one-dimensional Ising anisotropic quantum antiferromagn …
The carboxyl segment of the mumps virus V protein associates with Stat proteins in vitro via a tryptophan-rich motif.
Nishio M, Garcin D, Simonet V, Kolakofsky D. Nishio M, et al. Virology. 2002 Aug 15;300(1):92-9. doi: 10.1006/viro.2002.1509. Virology. 2002. PMID: 12202209 Free article.
This suggests that the specific degradation of these Stat proteins is not determined by complex formation, but presumably at some later stage of the degradation pathway. V/Stat complex formation requires a specific carboxyl segment of V. ...Our results suggest that …
This suggests that the specific degradation of these Stat proteins is not determined by complex formation, but presumably at some later stag …
Gate-Defined One-Dimensional Channel and Broken Symmetry States in MoS2 van der Waals Heterostructures.
Pisoni R, Lee Y, Overweg H, Eich M, Simonet P, Watanabe K, Taniguchi T, Gorbachev R, Ihn T, Ensslin K. Pisoni R, et al. Nano Lett. 2017 Aug 9;17(8):5008-5011. doi: 10.1021/acs.nanolett.7b02186. Epub 2017 Jul 7. Nano Lett. 2017. PMID: 28686030
In the bulk, we observe an electron mobility as high as 7000 cm(2)/(V s) at a density of 3 10(12) cm(-2) at a temperature of 1.9 K. ...
In the bulk, we observe an electron mobility as high as 7000 cm(2)/(V s) at a density of 3 10(12) cm(-2) at a temperature of 1.9 K. . …
Protection against Yersinia pseudotuberculosis infection conferred by a Lactococcus lactis mucosal delivery vector secreting LcrV.
Daniel C, Sebbane F, Poiret S, Goudercourt D, Dewulf J, Mullet C, Simonet M, Pot B. Daniel C, et al. Vaccine. 2009 Feb 18;27(8):1141-4. doi: 10.1016/j.vaccine.2008.12.022. Epub 2009 Jan 9. Vaccine. 2009. PMID: 19135495
Herein, we sought to evaluate the potential of a recombinant Lactococcus lactis strain secreting the Yersinia pseudotuberculosis low-calcium response V (LcrV) antigen for mucosal vaccination against Yersinia infections. ...
Herein, we sought to evaluate the potential of a recombinant Lactococcus lactis strain secreting the Yersinia pseudotuberculosis low-calcium …
Modulation of Vibrio cholerae porin function by acidic pH.
Duret G, Simonet V, Delcour AH. Duret G, et al. Channels (Austin). 2007 Mar-Apr;1(2):70-9. doi: 10.4161/chan.3983. Epub 2007 Feb 8. Channels (Austin). 2007. PMID: 18690017
Because of their localization and the regulation of their expression in response to these external factors, the OmpU and OmpT porins of V. cholerae are thought to be involved in the adaptation of the bacteria to the host environment. ...
Because of their localization and the regulation of their expression in response to these external factors, the OmpU and OmpT porins of V …
The Vibrio cholerae porins OmpU and OmpT have distinct channel properties.
Simonet VC, Baslé A, Klose KE, Delcour AH. Simonet VC, et al. J Biol Chem. 2003 May 9;278(19):17539-45. doi: 10.1074/jbc.M301202200. Epub 2003 Feb 25. J Biol Chem. 2003. PMID: 12606562 Free article.
OmpT is a much more dynamic channel than OmpU, displaying frequent and prolonged closures, even at low transmembrane potentials. With a critical voltage for closure V(c) of approximately +/-90 mV, OmpT is much more voltage-sensitive than OmpU (with a V(c) of approxi …
OmpT is a much more dynamic channel than OmpU, displaying frequent and prolonged closures, even at low transmembrane potentials. With a crit …
Genetic Association Analyses Highlight IL6, ALPL, and NAV1 As 3 New Susceptibility Genes Underlying Calcific Aortic Valve Stenosis.
Thériault S, Dina C, Messika-Zeitoun D, Le Scouarnec S, Capoulade R, Gaudreault N, Rigade S, Li Z, Simonet F, Lamontagne M, Clavel MA, Arsenault BJ, Boureau AS, Lecointe S, Baron E, Bonnaud S, Karakachoff M, Charpentier E, Fellah I, Roussel JC, Philippe Verhoye J, Baufreton C, Probst V, Roussel R; D.E.S.I.R. Study Group; Redon R, Dagenais F, Pibarot P, Mathieu P, Le Tourneau T, Bossé Y, Schott JJ. Thériault S, et al. Circ Genom Precis Med. 2019 Oct;12(10):e002617. doi: 10.1161/CIRCGEN.119.002617. Epub 2019 Oct 15. Circ Genom Precis Med. 2019. PMID: 32141789 Free article.
24 results