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461 results

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Showing results for vitro lobo
Search for Vítor Lobo instead (1 results)
The Effects of Dietary Interventions on Brain Aging and Neurological Diseases.
Lobo F, Haase J, Brandhorst S. Lobo F, et al. Nutrients. 2022 Nov 30;14(23):5086. doi: 10.3390/nu14235086. Nutrients. 2022. PMID: 36501116 Free PMC article. Review.
Dietary interventions can ameliorate age-related neurological decline. Decades of research of in vitro studies, animal models, and clinical trials support their ability and efficacy to improve behavioral outcomes by inducing biochemical and physiological changes that lead …
Dietary interventions can ameliorate age-related neurological decline. Decades of research of in vitro studies, animal models, and cl …
Ionizable Lipid Nanoparticle-Mediated Delivery of Plasmid DNA in Cardiomyocytes.
Scalzo S, Santos AK, Ferreira HAS, Costa PA, Prazeres PHDM, da Silva NJA, Guimarães LC, E Silva MM, Rodrigues Alves MTR, Viana CTR, Jesus ICG, Rodrigues AP, Birbrair A, Lobo AO, Frezard F, Mitchell MJ, Guatimosim S, Guimaraes PPG. Scalzo S, et al. Int J Nanomedicine. 2022 Jun 30;17:2865-2881. doi: 10.2147/IJN.S366962. eCollection 2022. Int J Nanomedicine. 2022. PMID: 35795081 Free PMC article.
RESULTS: By varying lipid molar ratios, the LNP formulation was optimized to deliver pDNA in cardiomyocytes with enhanced gene expression in vitro and in vivo, with negligible toxicity. In vitro, our lead LNP was able to reach a gene expression greater than 80%. ...
RESULTS: By varying lipid molar ratios, the LNP formulation was optimized to deliver pDNA in cardiomyocytes with enhanced gene expression in …
Generation and proof-of-concept for allogeneic CD123 CAR-Delta One T (DOT) cells in acute myeloid leukemia.
Sánchez Martínez D, Tirado N, Mensurado S, Martínez-Moreno A, Romecín P, Gutiérrez Agüera F, Correia DV, Silva-Santos B, Menéndez P. Sánchez Martínez D, et al. J Immunother Cancer. 2022 Sep;10(9):e005400. doi: 10.1136/jitc-2022-005400. J Immunother Cancer. 2022. PMID: 36162920 Free PMC article.
RESULTS: CD123CAR-DOTs showed vigorous, superior to control DOTs, cytotoxicity against AML cell lines and primary samples both in vitro and in vivo, even on tumor rechallenge. CONCLUSIONS: Our results provide the proof-of-concept for a DOT-based next-generation allogeneic …
RESULTS: CD123CAR-DOTs showed vigorous, superior to control DOTs, cytotoxicity against AML cell lines and primary samples both in vitro …
In vitro maturation: a committee opinion.
Practice Committees of the American Society for Reproductive Medicine and the Society for Assisted Reproductive Technology. Practice Committees of the American Society for Reproductive Medicine and the Society for Assisted Reproductive Technology. Fertil Steril. 2013 Mar 1;99(3):663-6. doi: 10.1016/j.fertnstert.2012.12.031. Epub 2013 Feb 1. Fertil Steril. 2013. PMID: 23391409 Free article.
The initial results of in vitro maturation suggest the potential for clinical application. However, at this time in vitro maturation should be performed only as an experimental procedure evaluating both efficacy and safety in carefully selected patients....
The initial results of in vitro maturation suggest the potential for clinical application. However, at this time in vitro matu …
In vitro high-content tissue models to address precision medicine challenges.
Afewerki S, Stocco TD, Rosa da Silva AD, Aguiar Furtado AS, Fernandes de Sousa G, Ruiz-Esparza GU, Webster TJ, Marciano FR, Strømme M, Zhang YS, Lobo AO. Afewerki S, et al. Mol Aspects Med. 2023 Jun;91:101108. doi: 10.1016/j.mam.2022.101108. Epub 2022 Aug 17. Mol Aspects Med. 2023. PMID: 35987701 Free PMC article. Review.
Here, the combination of organ-on-a-chip and bioprinting into engineering high-content in vitro tissue models is envisioned to address some precision medicine challenges. ...This could enable facile advances of important tools, diagnostics, and better physiologically repre …
Here, the combination of organ-on-a-chip and bioprinting into engineering high-content in vitro tissue models is envisioned to addres …
Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment.
Acúrcio RC, Pozzi S, Carreira B, Pojo M, Gómez-Cebrián N, Casimiro S, Fernandes A, Barateiro A, Farricha V, Brito J, Leandro AP, Salvador JAR, Graça L, Puchades-Carrasco L, Costa L, Satchi-Fainaro R, Guedes RC, Florindo HF. Acúrcio RC, et al. J Immunother Cancer. 2022 Jul;10(7):e004695. doi: 10.1136/jitc-2022-004695. J Immunother Cancer. 2022. PMID: 35863821 Free PMC article.
To that end, we employed in silico analyses combined with in vitro, ex vivo, and in vivo experimental studies to assess the ability of novel compounds to modulate PD-1/PD-L1 interaction and enhance T-cell function. ...
To that end, we employed in silico analyses combined with in vitro, ex vivo, and in vivo experimental studies to assess the ability o …
CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia.
Cardoso BA, Duque M, Gírio A, Fragoso R, Oliveira ML, Allen JR, Martins LR, Correia NC, Silveira AB, Veloso A, Kimura S, Demoen L, Matthijssens F, Jeha S, Cheng C, Pui CH, Grosso AR, Neto JL, De Almeida SF, Van Vlieberghe P, Mullighan CG, Yunes JA, Langenau DM, Pflumio F, Barata JT. Cardoso BA, et al. Haematologica. 2023 Dec 7. doi: 10.3324/haematol.2023.282854. Online ahead of print. Haematologica. 2023. PMID: 38058200 Free article.
In agreement, overexpression of CASZ1b in both Ba/F3 and T-ALL cells leads to the activation of PI3K signaling pathway, which is required for CASZ1b-mediated transformation of Ba/F3 cells in vitro and malignant expansion in vivo. We further demonstrate that CASZ1b cooperat …
In agreement, overexpression of CASZ1b in both Ba/F3 and T-ALL cells leads to the activation of PI3K signaling pathway, which is required fo …
Nanoparticle-Based Treatment in Glioblastoma.
Roque D, Cruz N, Ferreira HA, Reis CP, Matela N, Herculano-Carvalho M, Cascão R, Faria CC. Roque D, et al. J Pers Med. 2023 Aug 29;13(9):1328. doi: 10.3390/jpm13091328. J Pers Med. 2023. PMID: 37763096 Free PMC article. Review.
Various methods of drug delivery that pass through the BBB, such as the stereotactic injection of nanoparticles, are being actively tested in vitro and in vivo in animal models. A significant variety of pre-clinical studies with polymeric nanoparticles for the treatment of …
Various methods of drug delivery that pass through the BBB, such as the stereotactic injection of nanoparticles, are being actively tested i …
Babesia divergens: A Drive to Survive.
Lobo CA, Cursino-Santos JR, Singh M, Rodriguez M. Lobo CA, et al. Pathogens. 2019 Jul 2;8(3):95. doi: 10.3390/pathogens8030095. Pathogens. 2019. PMID: 31269710 Free PMC article. Review.
Central to its pathogenesis is the ability of the parasite to invade host red blood cells of diverse species, and, once in the host blood stream, to manipulate the composition of its population to allow it to endure unfavorable conditions. Here we will review key in vitro …
Central to its pathogenesis is the ability of the parasite to invade host red blood cells of diverse species, and, once in the host blood st …
Role of assisted hatching in in vitro fertilization: a guideline.
Practice Committee of the American Society for Reproductive Medicine; Practice Committee of the Society for Assisted Reproductive Technology. Practice Committee of the American Society for Reproductive Medicine, et al. Fertil Steril. 2014 Aug;102(2):348-51. doi: 10.1016/j.fertnstert.2014.05.034. Epub 2014 Jun 18. Fertil Steril. 2014. PMID: 24951365 Free article. Review.
There is good evidence that assisted hatching (AH) slightly improves clinical pregnancy rates, particularly in poor prognosis patients, including those with prior failed in vitro fertilization (IVF) cycles. Due to a limited number of studies, there is insufficient evidence …
There is good evidence that assisted hatching (AH) slightly improves clinical pregnancy rates, particularly in poor prognosis patients, incl …
461 results