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Page 1
A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy.
Bioconjug Chem. 2022 Jun 15;33(6):1210-1221. doi: 10.1021/acs.bioconjchem.2c00178. Epub 2022 Jun 3.
Bioconjug Chem. 2022.
PMID: 35658441
Free PMC article.
Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target.
Brzezinka K, Nevedomskaya E, Lesche R, Haegebarth A, Ter Laak A, Fernández-Montalván AE, Eberspaecher U, Werbeck ND, Moenning U, Siegel S, Haendler B, Eheim AL, Stresemann C.
Brzezinka K, et al. Among authors: eberspaecher u.
Cancers (Basel). 2020 Jan 14;12(1):201. doi: 10.3390/cancers12010201.
Cancers (Basel). 2020.
PMID: 31947537
Free PMC article.
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Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5.
Nguyen D, Lemos C, Wortmann L, Eis K, Holton SJ, Boemer U, Moosmayer D, Eberspaecher U, Weiske J, Lechner C, Prechtl S, Suelzle D, Siegel F, Prinz F, Lesche R, Nicke B, Nowak-Reppel K, Himmel H, Mumberg D, von Nussbaum F, Nising CF, Bauser M, Haegebarth A.
Nguyen D, et al. Among authors: eberspaecher u.
J Med Chem. 2019 Jan 24;62(2):928-940. doi: 10.1021/acs.jmedchem.8b01606. Epub 2019 Jan 9.
J Med Chem. 2019.
PMID: 30563338
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Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase.
Schulze VK, Klar U, Kosemund D, Wengner AM, Siemeister G, Stöckigt D, Neuhaus R, Lienau P, Bader B, Prechtl S, Holton SJ, Briem H, Marquardt T, Schirok H, Jautelat R, Bohlmann R, Nguyen D, Fernández-Montalván AE, Bömer U, Eberspaecher U, Brüning M, Döhr O, Raschke M, Kreft B, Mumberg D, Ziegelbauer K, Brands M, von Nussbaum F, Koppitz M.
Schulze VK, et al. Among authors: eberspaecher u.
J Med Chem. 2020 Aug 13;63(15):8025-8042. doi: 10.1021/acs.jmedchem.9b02035. Epub 2020 Apr 27.
J Med Chem. 2020.
PMID: 32338514
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Identifying protein construct variants with increased crystallization propensity--a case study.
Malawski GA, Hillig RC, Monteclaro F, Eberspaecher U, Schmitz AA, Crusius K, Huber M, Egner U, Donner P, Müller-Tiemann B.
Malawski GA, et al. Among authors: eberspaecher u.
Protein Sci. 2006 Dec;15(12):2718-28. doi: 10.1110/ps.062491906.
Protein Sci. 2006.
PMID: 17132859
Free PMC article.
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Structure of wild-type Plk-1 kinase domain in complex with a selective DARPin.
Bandeiras TM, Hillig RC, Matias PM, Eberspaecher U, Fanghänel J, Thomaz M, Miranda S, Crusius K, Pütter V, Amstutz P, Gulotti-Georgieva M, Binz HK, Holz C, Schmitz AA, Lang C, Donner P, Egner U, Carrondo MA, Müller-Tiemann B.
Bandeiras TM, et al. Among authors: eberspaecher u.
Acta Crystallogr D Biol Crystallogr. 2008 Apr;64(Pt 4):339-53. doi: 10.1107/S0907444907068217. Epub 2008 Mar 19.
Acta Crystallogr D Biol Crystallogr. 2008.
PMID: 18391401
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Structural basis for a high affinity inhibitor bound to protein kinase MK2.
Hillig RC, Eberspaecher U, Monteclaro F, Huber M, Nguyen D, Mengel A, Muller-Tiemann B, Egner U.
Hillig RC, et al. Among authors: eberspaecher u.
J Mol Biol. 2007 Jun 8;369(3):735-45. doi: 10.1016/j.jmb.2007.03.004. Epub 2007 Mar 12.
J Mol Biol. 2007.
PMID: 17449059
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