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Machine learning-driven multifunctional peptide engineering for sustained ocular drug delivery.
Hsueh HT, Chou RT, Rai U, Liyanage W, Kim YC, Appell MB, Pejavar J, Leo KT, Davison C, Kolodziejski P, Mozzer A, Kwon H, Sista M, Anders NM, Hemingway A, Rompicharla SVK, Edwards M, Pitha I, Hanes J, Cummings MP, Ensign LM. Hsueh HT, et al. Among authors: rai u. Nat Commun. 2023 May 2;14(1):2509. doi: 10.1038/s41467-023-38056-w. Nat Commun. 2023. PMID: 37130851 Free PMC article.
Engineered peptide-drug conjugate provides sustained protection of retinal ganglion cells with topical administration in rats.
Hsueh HT, Chou RT, Rai U, Kolodziejski P, Liyanage W, Pejavar J, Mozzer A, Davison C, Appell MB, Kim YC, Leo KT, Kwon H, Sista M, Anders NM, Hemingway A, Rompicharla SVK, Pitha I, Zack DJ, Hanes J, Cummings MP, Ensign LM. Hsueh HT, et al. Among authors: rai u. J Control Release. 2023 Oct;362:371-380. doi: 10.1016/j.jconrel.2023.08.058. Epub 2023 Sep 4. J Control Release. 2023. PMID: 37657693
A hypotonic gel-forming eye drop provides enhanced intraocular delivery of a kinase inhibitor with melanin-binding properties for sustained protection of retinal ganglion cells.
Kim YC, Hsueh HT, Shin MD, Berlinicke CA, Han H, Anders NM, Hemingway A, Leo KT, Chou RT, Kwon H, Appell MB, Rai U, Kolodziejski P, Eberhart C, Pitha I, Zack DJ, Hanes J, Ensign LM. Kim YC, et al. Among authors: rai u. Drug Deliv Transl Res. 2022 Apr;12(4):826-837. doi: 10.1007/s13346-021-00987-6. Epub 2021 Apr 26. Drug Deliv Transl Res. 2022. PMID: 33900546 Free PMC article.
Ion-Complex Microcrystal Formulation Provides Sustained Delivery of a Multimodal Kinase Inhibitor from the Subconjunctival Space for Protection of Retinal Ganglion Cells.
Hsueh HT, Kim YC, Pitha I, Shin MD, Berlinicke CA, Chou RT, Kimball E, Schaub J, Quillen S, Leo KT, Han H, Xiao A, Kim Y, Appell M, Rai U, Kwon H, Kolodziejski P, Ogunnaike L, Anders NM, Hemingway A, Jefferys JL, Date AA, Eberhart C, Johnson TV, Quigley HA, Zack DJ, Hanes J, Ensign LM. Hsueh HT, et al. Among authors: rai u. Pharmaceutics. 2021 May 1;13(5):647. doi: 10.3390/pharmaceutics13050647. Pharmaceutics. 2021. PMID: 34062883 Free PMC article.
The active Zot domain (aa 288-293) increases ZO-1 and myosin 1C serine/threonine phosphorylation, alters interaction between ZO-1 and its binding partners, and induces tight junction disassembly through proteinase activated receptor 2 activation.
Goldblum SE, Rai U, Tripathi A, Thakar M, De Leo L, Di Toro N, Not T, Ramachandran R, Puche AC, Hollenberg MD, Fasano A. Goldblum SE, et al. Among authors: rai u. FASEB J. 2011 Jan;25(1):144-58. doi: 10.1096/fj.10-158972. Epub 2010 Sep 17. FASEB J. 2011. PMID: 20852064 Free PMC article.