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Page 1
Discovery of New Imidazo[2,1-b]thiazole Derivatives as Potent Pan-RAF Inhibitors with Promising In Vitro and In Vivo Anti-melanoma Activity.
Abdel-Maksoud MS, El-Gamal MI, Lee BS, Gamal El-Din MM, Jeon HR, Kwon D, Ammar UM, Mersal KI, Ali EMH, Lee KT, Yoo KH, Han DK, Lee JK, Kim G, Choi HS, Kwon YJ, Lee KH, Oh CH. Abdel-Maksoud MS, et al. Among authors: ammar um. J Med Chem. 2021 May 27;64(10):6877-6901. doi: 10.1021/acs.jmedchem.1c00230. Epub 2021 May 17. J Med Chem. 2021. PMID: 33999621 Free article.
Scaffold Repurposing Reveals New Nanomolar Phosphodiesterase Type 5 (PDE5) Inhibitors Based on Pyridopyrazinone Scaffold: Investigation of In Vitro and In Silico Properties.
Amin KM, El-Badry OM, Abdel Rahman DE, Abdellattif MH, Abourehab MAS, El-Maghrabey MH, Elsaid FG, El Hamd MA, Elkamhawy A, Ammar UM. Amin KM, et al. Among authors: ammar um. Pharmaceutics. 2022 Sep 15;14(9):1954. doi: 10.3390/pharmaceutics14091954. Pharmaceutics. 2022. PMID: 36145702 Free PMC article.
Design, synthesis, biological evaluation, and docking studies of novel (imidazol-5-yl)pyrimidine-based derivatives as dual BRAFV600E/p38α inhibitors.
Ali EMH, El-Telbany RFA, Abdel-Maksoud MS, Ammar UM, Mersal KI, Zaraei SO, El-Gamal MI, Choi SI, Lee KT, Kim HK, Lee KH, Oh CH. Ali EMH, et al. Among authors: ammar um. Eur J Med Chem. 2021 Apr 5;215:113277. doi: 10.1016/j.ejmech.2021.113277. Epub 2021 Feb 7. Eur J Med Chem. 2021. PMID: 33601311 Free article.
2-(3-Bromophenyl)-8-fluoroquinazoline-4-carboxylic Acid as a Novel and Selective Aurora A Kinase Inhibitory Lead with Apoptosis Properties: Design, Synthesis, In Vitro and In Silico Biological Evaluation.
Elsherbeny MH, Ammar UM, Abdellattif MH, Abourehab MAS, Abdeen A, Ibrahim SF, Abdelrahaman D, Mady W, Roh EJ, Elkamhawy A. Elsherbeny MH, et al. Among authors: ammar um. Life (Basel). 2022 Jun 10;12(6):876. doi: 10.3390/life12060876. Life (Basel). 2022. PMID: 35743907 Free PMC article.
Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells.
Mersal KI, Abdel-Maksoud MS, Ali EMH, Ammar UM, Zaraei SO, Haque MM, Das T, Hassan NF, Kim EE, Lee JS, Park H, Lee KH, El-Gamal MI, Kim HK, Ibrahim TM, Oh CH. Mersal KI, et al. Among authors: ammar um. Eur J Med Chem. 2023 Dec 5;261:115779. doi: 10.1016/j.ejmech.2023.115779. Epub 2023 Sep 15. Eur J Med Chem. 2023. PMID: 37776574
16 results