Pharmacokinetics of orally administered ibuprofen in African and Asian elephants (Loxodonta africana and Elephas maximus).
J Zoo Wildl Med. 2007 Jun;38(2):258-68. doi: 10.1638/1042-7260(2007)038[0258:POOAII]2.0.CO;2.
J Zoo Wildl Med. 2007.
PMID: 17679510
The volume of distribution was estimated to be between 322 and 356 ml/kg R(-) and 133 and 173 ml/kg S(+) in Asian elephants and 360-431 ml/kg R(-) and 179-207 ml/kg S(+) in African elephants. Steady-state serum concentrations of ibuprofen ranged from 2.2 to 10.5 mic …
The volume of distribution was estimated to be between 322 and 356 ml/kg R(-) and 133 and 173 ml/kg S(+) in Asian elephants and 360-4 …