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Year Number of Results
1973 1
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1985 7
1986 6
1987 17
1988 22
1989 30
1990 45
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1992 44
1993 48
1994 62
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1999 70
2000 64
2001 68
2002 59
2003 75
2004 73
2005 58
2006 93
2007 87
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2024 5

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1,977 results

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The following term was not found in PubMed: Paragahawewa
Page 1
Bicyclic peptide-based assay for uPA cancer biomarker.
Moro G, Severin Sfragano P, Ghirardo J, Mazzocato Y, Angelini A, Palchetti I, Polo F. Moro G, et al. Biosens Bioelectron. 2022 Oct 1;213:114477. doi: 10.1016/j.bios.2022.114477. Epub 2022 Jun 16. Biosens Bioelectron. 2022. PMID: 35751954
This case study compares the performance of a biosensing platform for the human biomarker urokinase-type plasminogen activator (h-uPA) when using two bicyclic peptides (P(1) and P(2)) with different affinities for the target protein. The bioreceptors P(1) and P(2) w …
This case study compares the performance of a biosensing platform for the human biomarker urokinase-type plasminogen activator (h- …
Ulipristal acetate: a new emergency contraceptive.
Sullivan JL, Bulloch MN. Sullivan JL, et al. Expert Rev Clin Pharmacol. 2011 Jul;4(4):417-27. doi: 10.1586/ecp.11.21. Expert Rev Clin Pharmacol. 2011. PMID: 22114852 Review.
This selective progesterone receptor modulator appears to be more effective than the levonorgestrel-containing emergency contraceptive, which must be taken within 72 h of unprotected intercourse. According to pharmacodynamic trials, UPA delays follicular maturation …
This selective progesterone receptor modulator appears to be more effective than the levonorgestrel-containing emergency contraceptive, whic …
uPA impairs cerebrovasodilation after hypoxia/ischemia through LRP and ERK MAPK.
Armstead WM, Cines DB, Bdeir K, Kulikovskaya I, Stein SC, Higazi AA. Armstead WM, et al. Brain Res. 2008 Sep 22;1231:121-31. doi: 10.1016/j.brainres.2008.06.115. Epub 2008 Jul 8. Brain Res. 2008. PMID: 18656457 Free PMC article.
CSF uPA increased from 9+/-2 to 52+/-8 and 140+/-21 ng/ml at 1 and 4 h after H/I, respectively. The LRP antagonist receptor associated protein (RAP) and anti-LRP antibody blunted the increase in CSF uPA at 1 h (17+/-2 ng/ml) but not 4 h p …
CSF uPA increased from 9+/-2 to 52+/-8 and 140+/-21 ng/ml at 1 and 4 h after H/I, respectively. The LRP antagonist rece …
Targeting uPA/uPAR in prostate cancer.
Li Y, Cozzi PJ. Li Y, et al. Cancer Treat Rev. 2007 Oct;33(6):521-7. doi: 10.1016/j.ctrv.2007.06.003. Epub 2007 Jul 19. Cancer Treat Rev. 2007. PMID: 17658220 Review.
Both uPA and uPAR are expressed at much higher levels in CaP tissues than in benign and normal prostate tissues. ...Therefore, much effort is currently being directed toward targeting aberrant uPA or uPAR activity in CaP. This review summarizes some important new fi …
Both uPA and uPAR are expressed at much higher levels in CaP tissues than in benign and normal prostate tissues. ...Therefore, much e …
Ulipristal acetate and its role in emergency contraception: a comment.
Peitsidis P. Peitsidis P. Expert Opin Pharmacother. 2012 Sep;13(13):1821-3. doi: 10.1517/14656566.2012.713349. Epub 2012 Aug 8. Expert Opin Pharmacother. 2012. PMID: 22873821
It acts by inhibiting ovulation and delaying implantation. Its effectiveness is active up to 120 h after sexual intercourse. UPA is safe and has a good tolerability profile. Health care practitioners should inform women of all reproductive ages that UPA is an …
It acts by inhibiting ovulation and delaying implantation. Its effectiveness is active up to 120 h after sexual intercourse. UPA …
Increased expression of the urokinase plasminogen activator system by Helicobacter pylori in gastric epithelial cells.
Kenny S, Duval C, Sammut SJ, Steele I, Pritchard DM, Atherton JC, Argent RH, Dimaline R, Dockray GJ, Varro A. Kenny S, et al. Am J Physiol Gastrointest Liver Physiol. 2008 Sep;295(3):G431-41. doi: 10.1152/ajpgi.90283.2008. Epub 2008 Jul 3. Am J Physiol Gastrointest Liver Physiol. 2008. PMID: 18599586 Free PMC article.
In each case expression was increased in response to H. pylori and for uPA, but not PAI-1 or uPAR, required the virulence factor CagE. H. pylori also stimulated soluble and cell surface-bound uPA activity, and both were further increased by PAI-1 knock …
In each case expression was increased in response to H. pylori and for uPA, but not PAI-1 or uPAR, required the virulence fact …
The Plasminogen Activation System Promotes Neurorepair in the Ischemic Brain.
Yepes M. Yepes M. Curr Drug Targets. 2019;20(9):953-959. doi: 10.2174/1389450120666181211144550. Curr Drug Targets. 2019. PMID: 30539695 Free PMC article. Review.
For example, plasminogen-dependent and - independent effects of tPA and uPA play a central role in the pathophysiological events that underlie one of the leading causes of mortality and disability in the world: cerebral ischemia. ...This restorative role of uPA has …
For example, plasminogen-dependent and - independent effects of tPA and uPA play a central role in the pathophysiological events that …
Components of the Plasminogen-Plasmin System as Biologic Markers for Cancer.
McMahon BJ, Kwaan HC. McMahon BJ, et al. Adv Exp Med Biol. 2015;867:145-56. doi: 10.1007/978-94-017-7215-0_10. Adv Exp Med Biol. 2015. PMID: 26530365 Review.
Members of the plasminogen-plasmin (PP) system participate in many physiologic functions. In particular, uPA, its receptor (uPAR) and its inhibitor PAI-1 play an important role in cell migration, cell proliferation and tissue remodeling. ...In cancer, they modulate the ess …
Members of the plasminogen-plasmin (PP) system participate in many physiologic functions. In particular, uPA, its receptor (uPAR) and …
Ulipristal acetate as an emergency contraceptive agent.
Martinez AM, Thomas MA. Martinez AM, et al. Expert Opin Pharmacother. 2012 Sep;13(13):1937-42. doi: 10.1517/14656566.2012.705832. Epub 2012 Jul 7. Expert Opin Pharmacother. 2012. PMID: 22770536 Review.
A new oral tablet for emergency contraception (EC), ulipristal acetate (UPA) , is a selective progesterone receptor modulator and can be used up to 120 h following unprotected intercourse, without an increase in adverse effects or a decrease in efficacy. AREAS COVER …
A new oral tablet for emergency contraception (EC), ulipristal acetate (UPA) , is a selective progesterone receptor modulator and can …
Urinary-type plasminogen activator (uPA) and its receptor (uPAR) in squamous cell carcinoma of the oral cavity.
Shi Z, Stack MS. Shi Z, et al. Biochem J. 2007 Oct 15;407(2):153-9. doi: 10.1042/BJ20071037. Biochem J. 2007. PMID: 17880283 Review.
The proteinase uPA binds a surface-anchored receptor designated uPAR (uPA receptor), focalizing proteolytic activity to the pericellular milieu. ...Correlative clinical data show elevated uPA-uPAR in oral tumour tissues, with tumours exhibiting high levels of …
The proteinase uPA binds a surface-anchored receptor designated uPAR (uPA receptor), focalizing proteolytic activity to the pe …
1,977 results