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1987 1
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2004 1
2006 1
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2010 1
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2012 2
2013 1
2014 5
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2016 1
2017 3
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31 results

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Page 1
Posttranslational modification of microtubules by the MATCAP detyrosinase.
Landskron L, Bak J, Adamopoulos A, Kaplani K, Moraiti M, van den Hengel LG, Song JY, Bleijerveld OB, Nieuwenhuis J, Heidebrecht T, Henneman L, Moutin MJ, Barisic M, Taraviras S, Perrakis A, Brummelkamp TR. Landskron L, et al. Science. 2022 May 20;376(6595):eabn6020. doi: 10.1126/science.abn6020. Epub 2022 May 20. Science. 2022. PMID: 35482892
The detyrosination-tyrosination cycle involves the removal and religation of the C-terminal tyrosine of alpha-tubulin and is implicated in cognitive, cardiac, and mitotic defects. ...
The detyrosination-tyrosination cycle involves the removal and religation of the C-terminal tyrosine of alpha-tubulin and is implicat …
Corneal neurotoxicity due to topical benzalkonium chloride.
Sarkar J, Chaudhary S, Namavari A, Ozturk O, Chang JH, Yco L, Sonawane S, Khanolkar V, Hallak J, Jain S. Sarkar J, et al. Invest Ophthalmol Vis Sci. 2012 Apr 6;53(4):1792-802. doi: 10.1167/iovs.11-8775. Invest Ophthalmol Vis Sci. 2012. PMID: 22410563 Free PMC article.
PURPOSE: The aim of this study was to determine and characterize the effect of topical application of benzalkonium chloride (BAK) on corneal nerves in vivo and in vitro. METHODS: Thy1-YFP+ neurofluorescent mouse eyes were treated topically with vehicle or BAK (0.01% …
PURPOSE: The aim of this study was to determine and characterize the effect of topical application of benzalkonium chloride (BAK) on …
Extracting Modified Microtubules from Mammalian Cells to Study Microtubule-Protein Complexes by Cryo-Electron Microscopy.
Bak J, Landskron L, Brummelkamp TR, Perrakis A. Bak J, et al. J Vis Exp. 2023 Mar 3;(193). doi: 10.3791/65126. J Vis Exp. 2023. PMID: 36939268
The extracted tubulin can then be used to prepare cryo-electron microscope grids with microtubules that are bound to a purified microtubule-binding protein of interest. As an example, we demonstrate the extraction of fully tyrosinated microtubules from cell lines engineere …
The extracted tubulin can then be used to prepare cryo-electron microscope grids with microtubules that are bound to a purified micro …
Tumor suppressor protein p53 promotes 2-methoxyestradiol-induced activation of Bak and Bax, leading to mitochondria-dependent apoptosis in human colon cancer HCT116 cells.
Lee JY, Jee SB, Park WY, Choi YJ, Kim B, Kim YH, Jun do Y, Kim YH. Lee JY, et al. J Microbiol Biotechnol. 2014 Dec 28;24(12):1654-63. doi: 10.4014/jmb.1405.05062. J Microbiol Biotechnol. 2014. PMID: 25179905 Free article.
Additionally, mitochondrial apoptotic events, including the activation of Bak and Bax, loss of deltapsim, activation of caspase-9 and -3, and cleavage of lamin A/C, were more dominantly induced in the presence of p53. The Bak-specific and Bax-specific siRNA approach …
Additionally, mitochondrial apoptotic events, including the activation of Bak and Bax, loss of deltapsim, activation of caspase-9 and …
Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover.
Rikka S, Quinsay MN, Thomas RL, Kubli DA, Zhang X, Murphy AN, Gustafsson ÅB. Rikka S, et al. Cell Death Differ. 2011 Apr;18(4):721-31. doi: 10.1038/cdd.2010.146. Epub 2010 Nov 19. Cell Death Differ. 2011. PMID: 21278801 Free PMC article.
In this study, we investigated the relationship between mitochondrial dysfunction and upregulation of autophagy in response to Bnip3 in cells lacking Bax and Bak. We found that Bnip3 induced mitochondrial autophagy in the absence of mitochondrial membrane permeabilization …
In this study, we investigated the relationship between mitochondrial dysfunction and upregulation of autophagy in response to Bnip3 in cell …
Identification of synthetic lethality of PLK1 inhibition and microtubule-destabilizing drugs.
Hugle M, Belz K, Fulda S. Hugle M, et al. Cell Death Differ. 2015 Dec;22(12):1946-56. doi: 10.1038/cdd.2015.59. Epub 2015 May 29. Cell Death Differ. 2015. PMID: 26024389 Free PMC article.
Mechanistically, BI 2536/VCR co-treatment triggers mitotic arrest, which initiates mitochondrial apoptosis by inactivation of antiapoptotic BCL-2 family proteins, followed by BAX/BAK activation, production of reactive oxygen species (ROS) and activation of caspase-dependen …
Mechanistically, BI 2536/VCR co-treatment triggers mitotic arrest, which initiates mitochondrial apoptosis by inactivation of antiapoptotic …
Nicotinic acid attenuates amyloid β1-42-induced mitochondrial dysfunction and inhibits the mitochondrial pathway of apoptosis in differentiated SH-SY5Y cells.
Litwiniuk A, Kalisz M, Domańska A, Chmielowska M, Martyńska L, Baranowska-Bik A, Bik W. Litwiniuk A, et al. Neurochem Int. 2024 May 22;178:105772. doi: 10.1016/j.neuint.2024.105772. Online ahead of print. Neurochem Int. 2024. PMID: 38789043
NA pre-incubation abolished Abeta(1-42) treatment-associated alterations of mRNA levels of synaptic genes and enhanced the relative beta3 Tubulin fluorescence intensity. NA eliminated the Abeta(1-42)-induced mitochondrial dysfunction by increasing the potential of mitochon …
NA pre-incubation abolished Abeta(1-42) treatment-associated alterations of mRNA levels of synaptic genes and enhanced the relative beta3 …
Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivo.
HuangFu WC, Chao MW, Cheng CC, Wei YC, Wu YW, Liou JP, Hsiao G, Lee YC, Yang CR. HuangFu WC, et al. Sci Rep. 2017 Feb 9;7:42291. doi: 10.1038/srep42291. Sci Rep. 2017. PMID: 28181578 Free PMC article.
We previously synthesized the novel synthetic 1-benzylindole derivative 21-900 and found that it inhibits histone deacetylase (HDAC) activities and tubulin assembly. Here we tested its effects on the human leukaemia cell lines HL-60 and MOLT-4 in vitro and in vivo. ...Furt …
We previously synthesized the novel synthetic 1-benzylindole derivative 21-900 and found that it inhibits histone deacetylase (HDAC) activit …
Cholix toxin, an eukaryotic elongation factor 2 ADP-ribosyltransferase, interacts with Prohibitins and induces apoptosis with mitochondrial dysfunction in human hepatocytes.
Yahiro K, Ogura K, Terasaki Y, Satoh M, Miyagi S, Terasaki M, Yamasaki E, Moss J. Yahiro K, et al. Cell Microbiol. 2019 Aug;21(8):e13033. doi: 10.1111/cmi.13033. Epub 2019 May 14. Cell Microbiol. 2019. PMID: 31009148 Free PMC article.
In contrast, transiently overexpressed PHB in hepatocytes attenuated Cholix-induced Bax/Bak conformational changes and PARP cleavage. In addition, Cholix-induced reactive oxygen species production and accumulation of fragmented mitochondria were enhanced in PHB-knockdown c …
In contrast, transiently overexpressed PHB in hepatocytes attenuated Cholix-induced Bax/Bak conformational changes and PARP cleavage. …
Apoptosis resistance, mitotic catastrophe, and loss of ploidy control in Burkitt lymphoma.
Chumduri C, Gillissen B, Richter A, Richter A, Milojkovic A, Overkamp T, Müller A, Pott C, Daniel PT. Chumduri C, et al. J Mol Med (Berl). 2015 May;93(5):559-72. doi: 10.1007/s00109-014-1242-2. Epub 2014 Dec 30. J Mol Med (Berl). 2015. PMID: 25548804
Mechanistically, apoptosis resistance was linked to failure of caspase activation, which was most pronounced in cells lacking the pro-apoptotic multidomain Bcl-2 homologs Bax and Bak. Pharmacological caspase inhibition promoted polyploidy upon exposure to paclitaxel and no …
Mechanistically, apoptosis resistance was linked to failure of caspase activation, which was most pronounced in cells lacking the pro-apopto …
31 results