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Page 1
CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease.
Tsagkaraki E, Nicoloro SM, DeSouza T, Solivan-Rivera J, Desai A, Lifshitz LM, Shen Y, Kelly M, Guilherme A, Henriques F, Amrani N, Ibraheim R, Rodriguez TC, Luk K, Maitland S, Friedline RH, Tauer L, Hu X, Kim JK, Wolfe SA, Sontheimer EJ, Corvera S, Czech MP. Tsagkaraki E, et al. Among authors: rodriguez tc. Nat Commun. 2021 Nov 26;12(1):6931. doi: 10.1038/s41467-021-27190-y. Nat Commun. 2021. PMID: 34836963 Free PMC article.
PAM-flexible genome editing with an engineered chimeric Cas9.
Zhao L, Koseki SRT, Silverstein RA, Amrani N, Peng C, Kramme C, Savic N, Pacesa M, Rodríguez TC, Stan T, Tysinger E, Hong L, Yudistyra V, Ponnapati MR, Jacobson JM, Church GM, Jakimo N, Truant R, Jinek M, Kleinstiver BP, Sontheimer EJ, Chatterjee P. Zhao L, et al. Among authors: rodriguez tc. Nat Commun. 2023 Oct 4;14(1):6175. doi: 10.1038/s41467-023-41829-y. Nat Commun. 2023. PMID: 37794046 Free PMC article.
Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo.
Ibraheim R, Tai PWL, Mir A, Javeed N, Wang J, Rodríguez TC, Namkung S, Nelson S, Khokhar ES, Mintzer E, Maitland S, Chen Z, Cao Y, Tsagkaraki E, Wolfe SA, Wang D, Pai AA, Xue W, Gao G, Sontheimer EJ. Ibraheim R, et al. Among authors: rodriguez tc. Nat Commun. 2021 Nov 1;12(1):6267. doi: 10.1038/s41467-021-26518-y. Nat Commun. 2021. PMID: 34725353 Free PMC article.
Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts.
Shin M, Chan IL, Cao Y, Gruntman AM, Lee J, Sousa J, Rodríguez TC, Echeverria D, Devi G, Debacker AJ, Moazami MP, Krishnamurthy PM, Rembetsy-Brown JM, Kelly K, Yukselen O, Donnard E, Parsons TJ, Khvorova A, Sontheimer EJ, Maehr R, Garber M, Watts JK. Shin M, et al. Among authors: rodriguez tc. Nucleic Acids Res. 2022 Aug 26;50(15):8418-8430. doi: 10.1093/nar/gkac630. Nucleic Acids Res. 2022. PMID: 35920332 Free PMC article.
Adapting dCas9-APEX2 for subnuclear proteomic profiling.
Gao XD, Rodríguez TC, Sontheimer EJ. Gao XD, et al. Among authors: rodriguez tc. Methods Enzymol. 2019;616:365-383. doi: 10.1016/bs.mie.2018.10.030. Epub 2018 Dec 10. Methods Enzymol. 2019. PMID: 30691651 Free PMC article.
Genome-wide detection and analysis of CRISPR-Cas off-targets.
Rodríguez TC, Dadafarin S, Pratt HE, Liu P, Amrani N, Zhu LJ. Rodríguez TC, et al. Prog Mol Biol Transl Sci. 2021;181:31-43. doi: 10.1016/bs.pmbts.2021.01.012. Epub 2021 Mar 4. Prog Mol Biol Transl Sci. 2021. PMID: 34127199