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Showing results for topgal
Search for Tobgyal instead (2 results)
TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro.
Hens JR, Wilson KM, Dann P, Chen X, Horowitz MC, Wysolmerski JJ. Hens JR, et al. J Bone Miner Res. 2005 Jul;20(7):1103-13. doi: 10.1359/JBMR.050210. Epub 2005 Feb 14. J Bone Miner Res. 2005. PMID: 15940363 Free article.
However, little is known of the details of Wnt signaling in the skeleton in vivo. We used Wnt indicator TOPGAL mice to identify which cells activated this pathway during bone development and in the mature skeleton. MATERIALS AND METHODS: We examined canonical Wnt signaling …
However, little is known of the details of Wnt signaling in the skeleton in vivo. We used Wnt indicator TOPGAL mice to identify which …
Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair.
Al Alam D, Green M, Tabatabai Irani R, Parsa S, Danopoulos S, Sala FG, Branch J, El Agha E, Tiozzo C, Voswinckel R, Jesudason EC, Warburton D, Bellusci S. Al Alam D, et al. PLoS One. 2011;6(8):e23139. doi: 10.1371/journal.pone.0023139. Epub 2011 Aug 9. PLoS One. 2011. PMID: 21858009 Free PMC article.
Our data show important differences between reporter mice. While TOPGAL and BATGAL lines demonstrate Wnt signaling well in early lung epithelium, BATGAL expression is markedly reduced in late embryonic and adult lungs. ...Interestingly, both TOPGAL and Axin2(LacZ) a …
Our data show important differences between reporter mice. While TOPGAL and BATGAL lines demonstrate Wnt signaling well in early lung …
Investigating tonic Wnt signaling throughout the adult CNS and in the hippocampal neurogenic niche of BatGal and ins-TopGal mice.
Garbe DS, Ring RH. Garbe DS, et al. Cell Mol Neurobiol. 2012 Oct;32(7):1159-74. doi: 10.1007/s10571-012-9841-3. Epub 2012 Apr 11. Cell Mol Neurobiol. 2012. PMID: 22491991
Using two independent transgenic beta-catenin-activated LacZ reporter mouse lines (BatGal and ins-TopGal), we demonstrate that Wnt/beta-catenin signaling is active in discrete regions of the adult mouse CNS. ...Thus our data using ins-TopGal mice are consistent with …
Using two independent transgenic beta-catenin-activated LacZ reporter mouse lines (BatGal and ins-TopGal), we demonstrate that Wnt/be …
Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation.
DasGupta R, Fuchs E. DasGupta R, et al. Development. 1999 Oct;126(20):4557-68. doi: 10.1242/dev.126.20.4557. Development. 1999. PMID: 10498690
In mice, TOPGAL expression was directly stimulated by a stabilized form of beta -catenin, but was also dependent upon LEF1/TCF3 in skin. During embryogenesis, TOPGAL activation occurred transiently in a subset of LEF1-positive cells of pluripotent ectoderm and under …
In mice, TOPGAL expression was directly stimulated by a stabilized form of beta -catenin, but was also dependent upon LEF1/TCF3 in sk …
Canonical Wnt signaling activity during synovial joint development.
Yamagami T, Molotkov A, Zhou CJ. Yamagami T, et al. J Mol Histol. 2009 Aug;40(4):311-6. doi: 10.1007/s10735-009-9242-1. Epub 2009 Nov 18. J Mol Histol. 2009. PMID: 19921490
During postnatal development, the TOPgal(+) articular chondrocytes were abundant at P7 and decreased from P10. A small number of TOPgal(+) articular chondrocytes were also found in adult joints. ...
During postnatal development, the TOPgal(+) articular chondrocytes were abundant at P7 and decreased from P10. A small number of T …
Osteogenic regulation of vascular calcification.
Towler DA, Shao JS, Cheng SL, Pingsterhaus JM, Loewy AP. Towler DA, et al. Ann N Y Acad Sci. 2006 Apr;1068:327-33. doi: 10.1196/annals.1346.036. Ann N Y Acad Sci. 2006. PMID: 16831933 Review.
Msx2 upregulates aortic Wnt signaling in vivo, revealed by the analysis of TOPGAL+ (Wnt reporter) versus CMV-Msx2Tg+; TOPGAL+ mice. Aortic Msx2 exerts pro-osteogenic signaling in vivo and in vitro, mediated in part via the enhancement of paracrine Wnt signaling. ...
Msx2 upregulates aortic Wnt signaling in vivo, revealed by the analysis of TOPGAL+ (Wnt reporter) versus CMV-Msx2Tg+; TOPGAL+ …
Transcription Factor β-Catenin Plays a Key Role in Fluid Flow Shear Stress-Mediated Glomerular Injury in Solitary Kidney.
Srivastava T, Heruth DP, Duncan RS, Rezaiekhaligh MH, Garola RE, Priya L, Zhou J, Boinpelly VC, Novak J, Ali MF, Joshi T, Alon US, Jiang Y, McCarthy ET, Savin VJ, Sharma R, Johnson ML, Sharma M. Srivastava T, et al. Cells. 2021 May 19;10(5):1253. doi: 10.3390/cells10051253. Cells. 2021. PMID: 34069476 Free PMC article.
The UNX of TOPGAL mice resulted in glomerular hypertrophy and increased the mesangial matrix consistent with hemodynamic adaptation. Uninephrectomized TOPGAL mice showed an increased beta-galactosidase expression at 4 weeks but not at 12 weeks, as assessed using imm …
The UNX of TOPGAL mice resulted in glomerular hypertrophy and increased the mesangial matrix consistent with hemodynamic adaptation. …
Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone.
Xuan F, Yano F, Mori D, Chijimatsu R, Maenohara Y, Nakamoto H, Mori Y, Makii Y, Oichi T, Taketo MM, Hojo H, Ohba S, Chung UI, Tanaka S, Saito T. Xuan F, et al. Arthritis Res Ther. 2019 Nov 27;21(1):247. doi: 10.1186/s13075-019-2041-5. Arthritis Res Ther. 2019. PMID: 31771658 Free PMC article.
METHODS: Wnt/beta-catenin signaling activity was analyzed using TOPGAL mice. We generated Prg4-Cre(ERT2);Ctnnb1(fl/fl) and Prg4-Cre(ERT2);Ctnnb1-ex3(fl/wt) mice for loss- and gain-of-function, respectively, of Wnt/beta-catenin signaling in the SFZ. ...RESULTS: Wnt/beta-cat …
METHODS: Wnt/beta-catenin signaling activity was analyzed using TOPGAL mice. We generated Prg4-Cre(ERT2);Ctnnb1(fl/fl) and Prg4-Cre(E …
Characterization of a transient TCF/LEF-responsive progenitor population in the embryonic mouse retina.
Fuhrmann S, Riesenberg AN, Mathiesen AM, Brown EC, Vetter ML, Brown NL. Fuhrmann S, et al. Invest Ophthalmol Vis Sci. 2009 Jan;50(1):432-40. doi: 10.1167/iovs.08-2270. Epub 2008 Jul 3. Invest Ophthalmol Vis Sci. 2009. PMID: 18599572 Free PMC article.
RESULTS: TOPgal reporter activation occurred transiently in a subpopulation of embryonic retinal progenitor cells. Axin2 was not expressed in the central retina, and TOPgal reporter expression persisted in the absence of beta-catenin. ...
RESULTS: TOPgal reporter activation occurred transiently in a subpopulation of embryonic retinal progenitor cells. Axin2 was not expr …
Fibroblast growth factor 10 is critical for liver growth during embryogenesis and controls hepatoblast survival via beta-catenin activation.
Berg T, Rountree CB, Lee L, Estrada J, Sala FG, Choe A, Veltmaat JM, De Langhe S, Lee R, Tsukamoto H, Crooks GM, Bellusci S, Wang KS. Berg T, et al. Hepatology. 2007 Oct;46(4):1187-97. doi: 10.1002/hep.21814. Hepatology. 2007. PMID: 17668871 Free PMC article.
A comparison of beta-galactosidase activity as a readout of Fgf10 expression in Fgf10(+/LacZ) mice and of beta-catenin activation in TOPGAL mice, demonstrated peak Fgf10 expression from E9 to E13.5 coinciding with peak beta-catenin activation. ...Moreover, hepatoblasts exp …
A comparison of beta-galactosidase activity as a readout of Fgf10 expression in Fgf10(+/LacZ) mice and of beta-catenin activation in TOPG …
87 results