Germline Elongator mutations in Sonic Hedgehog medulloblastoma.
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Nature. 2020 Apr;580(7803):396-401. doi: 10.1038/s41586-020-2164-5. Epub 2020 Apr 1.
Nature. 2020.
PMID: 32296180
Free PMC article.
ELP1 is the largest subunit of the evolutionarily conserved Elongator complex, which catalyses translational elongation through tRNA modifications at the wobble (U(34)) position(5,6). Tumours from patients with ELP1-associated MB(SHH) were characterized by a destabilized E …
ELP1 is the largest subunit of the evolutionarily conserved Elongator complex, which catalyses translational elongation through tRNA …