Nitazoxanide May Modify the Course of Progressive Multifocal Leukoencephalopathy

Timo J Hautala; Ludmila Perelygina; Tytti Vuorinen; Nina M Hautala; Päivi M Hägg; Michaela K Bode; Harri T Rusanen; Marjo H Renko; Virpi Glumoff; Nicholas Schwab; Tilman Schneider-Hohendorf; Jean-Luc Murk; Kathleen E Sullivan; Mikko R J Seppänen

doi:10.1007/s10875-017-0463-x

Nitazoxanide May Modify the Course of Progressive Multifocal Leukoencephalopathy

J Clin Immunol. 2018 Jan;38(1):4-6. doi: 10.1007/s10875-017-0463-x. Epub 2017 Nov 20.

Authors

Affiliations

¹ Department of Internal Medicine, Oulu University Hospital, P.O. Box 20, FIN-90029 OYS, Oulu, Finland. timo.hautala@ppshp.fi.
² Viral Vaccine Preventable Diseases Branch, Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
³ Department of Virology, University of Turku, Turku, Finland.
⁴ Department of Clinical Virology, Turku University Hospital, Turku, Finland.
⁵ Department of Ophthalmology, Medical Research Center and PEDEGO Research Unit, University of Oulu and Oulu University Hospital, Oulu, Finland.
⁶ Department of Dermatology, Medical Research Center and PEDEGO Research Unit, University of Oulu and Oulu University Hospital, Oulu, Finland.
⁷ Department of Diagnostic Radiology, PEDEGO Research Unit and Oulu University Hospital, Oulu, Finland.
⁸ Department of Neurology, PEDEGO Research Unit and Oulu University Hospital, Oulu, Finland.
⁹ Department of Pediatrics, PEDEGO Research Unit and Oulu University Hospital, Oulu, Finland.
¹⁰ Research Unit of Biomedicine, University of Oulu, Oulu, Finland.
¹¹ Department of Neurology, University of Münster, Münster, Germany.
¹² Department of Medical Microbiology and Infection control, University Medical Center Utrecht, Utrecht, The Netherlands.
¹³ Laboratory of Medical Microbiology and Immunology, St. Elisabeth Hospital Tilburg, Tilburg, The Netherlands.
¹⁴ Division of Allergy Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
¹⁵ Immunodeficiency Unit, Inflammation Center and Center for Rare Diseases, Children's Hospital, Helsinki University and Helsinki University Hospital, Helsinki, Finland.

No abstract available

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Antiparasitic Agents / therapeutic use*
Antiviral Agents / therapeutic use*
Brain / diagnostic imaging*
Brain / pathology
Epilepsy
Female
Humans
Immunologic Deficiency Syndromes / complications
Immunologic Deficiency Syndromes / drug therapy*
Leukoencephalopathy, Progressive Multifocal / complications
Leukoencephalopathy, Progressive Multifocal / drug therapy*
Magnetic Resonance Imaging
Nitro Compounds
Polyomavirus / physiology*
Polyomavirus Infections / diagnosis*
Skin / pathology
Thiazoles / therapeutic use*

Substances

Antiparasitic Agents
Antiviral Agents
Nitro Compounds
Thiazoles
nitazoxanide