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1969 1
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1973 2
1974 5
1975 2
1976 4
1977 10
1978 6
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1980 5
1981 4
1982 5
1983 4
1984 3
1985 3
1986 5
1987 7
1988 32
1989 56
1990 20
1991 18
1992 20
1993 21
1994 26
1995 31
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1998 110
1999 121
2000 156
2001 154
2002 199
2003 210
2004 262
2005 263
2006 300
2007 342
2008 373
2009 357
2010 403
2011 506
2012 474
2013 530
2014 593
2015 817
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The following term was not found in PubMed: Napier-Munn
Page 1
TIM-3: An update on immunotherapy.
Zhao L, Cheng S, Fan L, Zhang B, Xu S. Zhao L, et al. Int Immunopharmacol. 2021 Oct;99:107933. doi: 10.1016/j.intimp.2021.107933. Epub 2021 Jul 2. Int Immunopharmacol. 2021. PMID: 34224993 Review.
Studies have shown that TIM-3 plays an important role in autoimmune diseases, chronic viral infections and tumors. A large amount of experimental data supports TIM-3 as an immune checkpoint, and targeting TIM-3 is a promising treatment method in current immun …
Studies have shown that TIM-3 plays an important role in autoimmune diseases, chronic viral infections and tumors. A large amount of …
Tim-3 regulates sepsis-induced immunosuppression by inhibiting the NF-kappaB signaling pathway in CD4 T cells.
Huang S, Liu D, Sun J, Zhang H, Zhang J, Wang Q, Gan L, Qu G, Qiu J, Deng J, Jiang J, Zeng L. Huang S, et al. Mol Ther. 2022 Mar 2;30(3):1227-1238. doi: 10.1016/j.ymthe.2021.12.013. Epub 2021 Dec 18. Mol Ther. 2022. PMID: 34933101 Free PMC article.
Conditional deletion of Tim-3 in CD4 T cells and systemic Tim-3 deletion both reduced mortality in response to sepsis in mice by preserving organ function. Tim-3(+) CD4 T cells exhibited reduced proliferative ability and elevated expression of inhibitory mark …
Conditional deletion of Tim-3 in CD4 T cells and systemic Tim-3 deletion both reduced mortality in response to sepsis in mice …
Molecular and clinical characterization of TIM-3 in glioma through 1,024 samples.
Li G, Wang Z, Zhang C, Liu X, Cai J, Wang Z, Hu H, Wu F, Bao Z, Liu Y, Zhao L, Liang T, Yang F, Huang R, Zhang W, Jiang T. Li G, et al. Oncoimmunology. 2017 Jul 28;6(8):e1328339. doi: 10.1080/2162402X.2017.1328339. eCollection 2017. Oncoimmunology. 2017. PMID: 28919992 Free PMC article.
Moreover, TIM-3 and PD-L1 played almost exactly the same inflammatory activation functions in glioma. Clinically, high expression of TIM-3 was an independent indicator of poor prognosis. Conclusion: The expression of TIM-3 is closely related to the pathology …
Moreover, TIM-3 and PD-L1 played almost exactly the same inflammatory activation functions in glioma. Clinically, high expression of …
Tim-3 aggravates podocyte injury in diabetic nephropathy by promoting macrophage activation via the NF-kappaB/TNF-alpha pathway.
Yang H, Xie T, Li D, Du X, Wang T, Li C, Song X, Xu L, Yi F, Liang X, Gao L, Yang X, Ma C. Yang H, et al. Mol Metab. 2019 May;23:24-36. doi: 10.1016/j.molmet.2019.02.007. Epub 2019 Feb 26. Mol Metab. 2019. PMID: 30862474 Free PMC article.
METHODS: We downregulated Tim-3 expression in kidney (intrarenal injection of Tim-3 shRNA expressing lentivirus or global Tim-3 knockout mice) and induced DN by streptozotocin (STZ). ...Similar effects were observed in mice with Tim-3 knockdown diabeti …
METHODS: We downregulated Tim-3 expression in kidney (intrarenal injection of Tim-3 shRNA expressing lentivirus or global T …
TIM-4 interference in Kupffer cells against CCL4-induced liver fibrosis by mediating Akt1/Mitophagy signalling pathway.
Wu H, Chen G, Wang J, Deng M, Yuan F, Gong J. Wu H, et al. Cell Prolif. 2020 Jan;53(1):e12731. doi: 10.1111/cpr.12731. Epub 2019 Nov 22. Cell Prolif. 2020. PMID: 31755616 Free PMC article.
However, the role of TIM-4 expressed by Kupffer cells (KCs) in liver fibrosis remains unclear. ...TIM-4 interference essentially contributed to liver fibrosis resolution. ...
However, the role of TIM-4 expressed by Kupffer cells (KCs) in liver fibrosis remains unclear. ...TIM-4 interference essential …
IL-6 promotes metastasis of non-small-cell lung cancer by up-regulating TIM-4 via NF-kappaB.
Liu W, Wang H, Bai F, Ding L, Huang Y, Lu C, Chen S, Li C, Yue X, Liang X, Ma C, Xu L, Gao L. Liu W, et al. Cell Prolif. 2020 Mar;53(3):e12776. doi: 10.1111/cpr.12776. Epub 2020 Feb 5. Cell Prolif. 2020. PMID: 32020709 Free PMC article.
Both TIM-4 and IL-6 promoted migration, invasion and EMT of NSCLC cells. Interestingly, TIM-4 knockdown reversed the role of IL-6 in NSCLC and IL-6 promoted metastasis of NSCLC by up-regulating TIM-4 via NF-kappaB. ...
Both TIM-4 and IL-6 promoted migration, invasion and EMT of NSCLC cells. Interestingly, TIM-4 knockdown reversed the role of I …
Immune regulation by Tim-3.
Banerjee H, Kane LP. Banerjee H, et al. F1000Res. 2018 Mar 14;7:316. doi: 10.12688/f1000research.13446.1. eCollection 2018. F1000Res. 2018. PMID: 29560265 Free PMC article. Review.
Thus, Tim-3 has been associated with both inhibitory and co-stimulatory function, depending in part on the specific cell type and immune response course. ...Thus, Tim-3 has emerged as a possible therapeutic target, which is being actively explored both pre-clinicall …
Thus, Tim-3 has been associated with both inhibitory and co-stimulatory function, depending in part on the specific cell type and imm …
Macrophage Tim-3 maintains intestinal homeostasis in DSS-induced colitis by suppressing neutrophil necroptosis.
Wang F, Zhou F, Peng J, Chen H, Xie J, Liu C, Xiong H, Chen S, Xue G, Zhou X, Xie Y. Wang F, et al. Redox Biol. 2024 Apr;70:103072. doi: 10.1016/j.redox.2024.103072. Epub 2024 Feb 2. Redox Biol. 2024. PMID: 38330550 Free PMC article.
Macrophage-specific Tim3-knockout (Tim-3(M-KO)) mice were generated to explore the function and mechanism of Tim-3 in dextran sodium sulfate (DSS)-induced colitis. ...Macrophage Tim-3 regulates neutrophil necroptosis via intracellular ROS signaling. ...
Macrophage-specific Tim3-knockout (Tim-3(M-KO)) mice were generated to explore the function and mechanism of Tim-3 in dextran …
Novel Roles of the Tim Family in Immune Regulation and Autoimmune Diseases.
Liu Y, Chen H, Chen Z, Qiu J, Pang H, Zhou Z. Liu Y, et al. Front Immunol. 2021 Sep 17;12:748787. doi: 10.3389/fimmu.2021.748787. eCollection 2021. Front Immunol. 2021. PMID: 34603337 Free PMC article. Review.
In recent years, the expression and function of Tims on different cells and the identification of new ligands for the Tim family have suggested that the Tim family plays a crucial role in immune regulation. In addition, the relationship between Tim family gen …
In recent years, the expression and function of Tims on different cells and the identification of new ligands for the Tim family have …
TIM-3 pathway dysregulation and targeting in cancer.
Zeidan AM, Komrokji RS, Brunner AM. Zeidan AM, et al. Expert Rev Anticancer Ther. 2021 May;21(5):523-534. doi: 10.1080/14737140.2021.1865814. Epub 2021 Jan 19. Expert Rev Anticancer Ther. 2021. PMID: 33334180 Review.
TIM-3 has been shown to promote immune tolerance, and overexpression of TIM-3 is associated with more aggressive or advanced disease and poor prognosis. AREAS COVERED: This review examines what is currently known regarding the biology of TIM-3 and clinical im …
TIM-3 has been shown to promote immune tolerance, and overexpression of TIM-3 is associated with more aggressive or advanced d …
13,856 results
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