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Long-term tolerance to skin commensals is established neonatally through a specialized dendritic cell subgroup.
Weckel A, Dhariwala MO, Ly K, Tran VM, Ojewumi OT, Riggs JB, Gonzalez JR, Dwyer LR, Okoro JN, Leech JM, Bacino MS, Cho GD, Merana G, Anandasabapathy N, Kumamoto Y, Scharschmidt TC. Weckel A, et al. Immunity. 2023 Jun 13;56(6):1239-1254.e7. doi: 10.1016/j.immuni.2023.03.008. Epub 2023 Apr 6. Immunity. 2023. PMID: 37028427
More particularly, CD301b(+) type 2 conventional dendritic cells (DCs) in neonatal skin were specifically capable of uptake and presentation of commensal antigens for the generation of regulatory T (Treg) cells. CD301b(+) DC2 were enriched for phagocytosis and maturation p …
More particularly, CD301b(+) type 2 conventional dendritic cells (DCs) in neonatal skin were specifically capable of uptake and presentation …
Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA.
Johnston SC, Easton JD, Farrant M, Barsan W, Conwit RA, Elm JJ, Kim AS, Lindblad AS, Palesch YY; Clinical Research Collaboration, Neurological Emergencies Treatment Trials Network, and the POINT Investigators. Johnston SC, et al. N Engl J Med. 2018 Jul 19;379(3):215-225. doi: 10.1056/NEJMoa1800410. Epub 2018 May 16. N Engl J Med. 2018. PMID: 29766750 Free PMC article. Clinical Trial.
Basolateral P2X₄channels stimulate ENaC activity in Xenopus cortical collecting duct A6 cells.
Thai TL, Yu L, Eaton DC, Duke BJ, Al-Khalili O, Lam HY, Ma H, Bao HF. Thai TL, et al. Am J Physiol Renal Physiol. 2014 Oct 1;307(7):F806-13. doi: 10.1152/ajprenal.00350.2013. Epub 2014 Aug 6. Am J Physiol Renal Physiol. 2014. PMID: 25100278 Free PMC article.
The effect of meSATP on ENaC activity was reduced after chelation of basolateral Ca2+ with EGTA or inhibition of phosphatidylinositol 3-kinase with LY-294002. Overall, our results show that ENaC is stimulated by P2X4receptor activation and that the stimulation is dependent …
The effect of meSATP on ENaC activity was reduced after chelation of basolateral Ca2+ with EGTA or inhibition of phosphatidylinositol 3-kina …