This study combines relevant theories and methods from economics and ecology to investigate design-driven transformation and upgrade paths for the long-term success of regional industries in the context of sustainable transformation, drawing on the design research literature's emphasis on sustainability, synergy, and a systemic approach. This evaluation may be thought of as a precondition for transformation. The regional industrial base dictates the upgrading route for sustainable transformation. Huaihua, a prefecture-level city in Hunan Province, China, serves as a case study for this investigation. Huaihua City's ecological footprints, human development index, and ecological welfare performance are used to evaluate the region's industrial base. A system based on quantitative data criteria and hierarchical analysis was built to choose top regional industries. The design study has promising implications for the sustainable transformation of major regional industries since it is an interdisciplinary, collaborative, and methodical type of research. Huaihua City, as a representative region of the less developed southwest region in China, designs a sustainable industrial transformation and upgrading path by providing a theoretical basis and quantitative measurement criteria for the sustainable transformation of regional industries.
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