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Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage.
Deng H, Gao Y, Trappetti V, Hertig D, Karatkevich D, Losmanova T, Urzi C, Ge H, Geest GA, Bruggmann R, Djonov V, Nuoffer JM, Vermathen P, Zamboni N, Riether C, Ochsenbein A, Peng RW, Kocher GJ, Schmid RA, Dorn P, Marti TM. Deng H, et al. Among authors: marti tm. Cell Mol Life Sci. 2022 Jul 25;79(8):445. doi: 10.1007/s00018-022-04453-5. Cell Mol Life Sci. 2022. PMID: 35877003 Free PMC article.
A New Immortalized Human Alveolar Epithelial Cell Model to Study Lung Injury and Toxicity on a Breathing Lung-On-Chip System.
Sengupta A, Roldan N, Kiener M, Froment L, Raggi G, Imler T, de Maddalena L, Rapet A, May T, Carius P, Schneider-Daum N, Lehr CM, Kruithof-de Julio M, Geiser T, Marti TM, Stucki JD, Hobi N, Guenat OT. Sengupta A, et al. Among authors: marti tm. Front Toxicol. 2022 Jun 17;4:840606. doi: 10.3389/ftox.2022.840606. eCollection 2022. Front Toxicol. 2022. PMID: 35832493 Free PMC article.
An optimized protocol for the generation and monitoring of conditional orthotopic lung cancer in the KP mouse model using an adeno-associated virus vector compatible with biosafety level 1.
Deng H, Ge H, Dubey C, Losmanova T, Medová M, Konstantinidou G, Mutlu SM, Birrer FE, Brodie TM, Stroka D, Wang W, Peng RW, Dorn P, Marti TM. Deng H, et al. Among authors: marti tm. Cancer Immunol Immunother. 2023 Dec;72(12):4457-4470. doi: 10.1007/s00262-023-03542-z. Epub 2023 Oct 5. Cancer Immunol Immunother. 2023. PMID: 37796299 Free PMC article.
Tumor Initiation Capacity and Therapy Resistance Are Differential Features of EMT-Related Subpopulations in the NSCLC Cell Line A549.
Tièche CC, Gao Y, Bührer ED, Hobi N, Berezowska SA, Wyler K, Froment L, Weis S, Peng RW, Bruggmann R, Schär P, Amrein MA, Hall SRR, Dorn P, Kocher G, Riether C, Ochsenbein A, Schmid RA, Marti TM. Tièche CC, et al. Among authors: marti tm. Neoplasia. 2019 Feb;21(2):185-196. doi: 10.1016/j.neo.2018.09.008. Epub 2018 Dec 27. Neoplasia. 2019. PMID: 30591423 Free PMC article.