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Year Number of Results
1994 1
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1999 1
2000 1
2001 1
2002 1
2003 4
2004 2
2005 2
2006 2
2007 1
2008 4
2009 3
2010 3
2011 1
2013 2
2014 2
2015 5
2016 2
2017 5
2018 2
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2020 2
2021 6
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54 results

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Page 1
Intravascular Survival and Extravasation of Tumor Cells.
Strilic B, Offermanns S. Strilic B, et al. Cancer Cell. 2017 Sep 11;32(3):282-293. doi: 10.1016/j.ccell.2017.07.001. Cancer Cell. 2017. PMID: 28898694 Free article. Review.
Within the bloodstream, they are exposed to severe stress due to loss of adhesion to extracellular matrix, hemodynamic shear forces, and attacks of the immune system, and only a few cells manage to extravasate and to form metastases. ...
Within the bloodstream, they are exposed to severe stress due to loss of adhesion to extracellular matrix, hemodynamic shear forces, …
Shear stress-regulated miR-27b controls pericyte recruitment by repressing SEMA6A and SEMA6D.
Demolli S, Doddaballapur A, Devraj K, Stark K, Manavski Y, Eckart A, Zehendner CM, Lucas T, Korff T, Hecker M, Massberg S, Liebner S, Kaluza D, Boon RA, Dimmeler S. Demolli S, et al. Cardiovasc Res. 2017 May 1;113(6):681-691. doi: 10.1093/cvr/cvx032. Cardiovasc Res. 2017. PMID: 28453731
AIMS: Vessel maturation involves the recruitment of mural cells such as pericytes and smooth muscle cells. Laminar shear stress is a major trigger for vessel maturation, but the molecular mechanisms by which shear stress affects recruitment of pericytes are unclear. …
AIMS: Vessel maturation involves the recruitment of mural cells such as pericytes and smooth muscle cells. Laminar shear stress is a …
The various states of von Willebrand factor and their function in physiology and pathophysiology.
Huck V, Schneider MF, Gorzelanny C, Schneider SW. Huck V, et al. Thromb Haemost. 2014 Apr 1;111(4):598-609. doi: 10.1160/TH13-09-0800. Epub 2014 Feb 27. Thromb Haemost. 2014. PMID: 24573248 Review.
The specific interactions of von Willebrand factor (VWF) with the vessel wall, platelets or other interfaces strongly depend on (a shear-induced) VWF activation. Shear flow has been shown to induce a conformational transition of VWF, but is modulated by its thermody …
The specific interactions of von Willebrand factor (VWF) with the vessel wall, platelets or other interfaces strongly depend on (a shear …
High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4+ T cell arrest on the inflamed BBB under flow in vitro.
Soldati S, Bär A, Vladymyrov M, Glavin D, McGrath JL, Gosselet F, Nishihara H, Goelz S, Engelhardt B. Soldati S, et al. J Neuroinflammation. 2023 May 23;20(1):123. doi: 10.1186/s12974-023-02797-8. J Neuroinflammation. 2023. PMID: 37221552 Free PMC article.
RESULTS: Making use of three different human in vitro BBB models and in vitro live-cell imaging we observed that NTZ mediated inhibition of alpha4-integrins failed to abrogate T cell arrest to the inflamed BBB under physiological flow. Complete inhibition of shear resistan …
RESULTS: Making use of three different human in vitro BBB models and in vitro live-cell imaging we observed that NTZ mediated inhibition of …
Contrast Ultrasound, Sonothrombolysis and Sonoperfusion in Cardiovascular Disease: Shifting to Theragnostic Clinical Trials.
El Kadi S, Porter TR, Verouden NJW, van Rossum AC, Kamp O. El Kadi S, et al. JACC Cardiovasc Imaging. 2022 Feb;15(2):345-360. doi: 10.1016/j.jcmg.2021.07.028. Epub 2021 Oct 13. JACC Cardiovasc Imaging. 2022. PMID: 34656483 Free PMC article. Review.
Visualization of intravascular contrast microbubbles is based on acoustic cavitation, the characteristic oscillation that results in changes in the reflected ultrasound waves. At high power, this acoustic response generates sufficient shear that is capable of enhancing end …
Visualization of intravascular contrast microbubbles is based on acoustic cavitation, the characteristic oscillation that results in changes …
Platelet collagen receptors.
Clemetson KJ, Clemetson JM. Clemetson KJ, et al. Thromb Haemost. 2001 Jul;86(1):189-97. Thromb Haemost. 2001. PMID: 11487007 Review.
In addition, GPIb-V-IX, can be considered as an indirect collagen receptor acting via von Willebrand factor as bridging molecule and is essential for platelet interactions with collagen at high shear rates. There is some evidence for additional receptors, which may regulat …
In addition, GPIb-V-IX, can be considered as an indirect collagen receptor acting via von Willebrand factor as bridging molecule and is esse …
Interfacial Adsorption Controls Particle Formation in Antibody Formulations Subjected to Extensional Flows and Hydrodynamic Shear.
Thite NG, Ghazvini S, Wallace N, Feldman N, Calderon CP, Randolph TW. Thite NG, et al. J Pharm Sci. 2023 Nov;112(11):2766-2777. doi: 10.1016/j.xphs.2023.07.010. Epub 2023 Jul 13. J Pharm Sci. 2023. PMID: 37453529
During their manufacturing and delivery to patients, therapeutic proteins are commonly exposed to various interfaces and to hydrodynamic shear forces. Although adsorption of proteins to solid-liquid interfaces is known to foster formation of protein aggregates and particle …
During their manufacturing and delivery to patients, therapeutic proteins are commonly exposed to various interfaces and to hydrodynamic …
Vascular endothelium and blood flow.
Busse R, Fleming I. Busse R, et al. Handb Exp Pharmacol. 2006;(176 Pt 2):43-78. doi: 10.1007/3-540-36028-x_2. Handb Exp Pharmacol. 2006. PMID: 16999224 Review.
This review is intended as an overview of the signalling mechanisms that link haemodynamic stimuli (such as shear stress and cyclic stretch) and endothelial cell perturbation to the activation of enzymes generating vasoactive autacoids....
This review is intended as an overview of the signalling mechanisms that link haemodynamic stimuli (such as shear stress and cyclic s …
Molecular mechanisms underlying the activation of eNOS.
Fleming I. Fleming I. Pflugers Arch. 2010 May;459(6):793-806. doi: 10.1007/s00424-009-0767-7. Epub 2009 Dec 13. Pflugers Arch. 2010. PMID: 20012875 Review.
Many of these effects are mediated by changes in the generation and release of the vasodilator nitric oxide (NO) in response to hemodynamic stimuli exerted on the luminal surface of endothelial cells by the streaming blood (shear stress) and the cyclic strain of the vascul …
Many of these effects are mediated by changes in the generation and release of the vasodilator nitric oxide (NO) in response to hemodynamic …
Shear stress-induced activation of the AMP-activated protein kinase regulates FoxO1a and angiopoietin-2 in endothelial cells.
Dixit M, Bess E, Fisslthaler B, Härtel FV, Noll T, Busse R, Fleming I. Dixit M, et al. Cardiovasc Res. 2008 Jan;77(1):160-8. doi: 10.1093/cvr/cvm017. Epub 2007 Sep 19. Cardiovasc Res. 2008. PMID: 18006475
METHODS AND RESULTS: Shear stress (12 dynes/cm2) elicited the phosphorylation, nuclear exclusion, and degradation of FoxO1a. Inhibition of Akt signalling using either a dominant negative (DN) mutant of Akt or downregulation of Gab1 largely failed to affect the shear …
METHODS AND RESULTS: Shear stress (12 dynes/cm2) elicited the phosphorylation, nuclear exclusion, and degradation of FoxO1a. Inhibiti …
54 results