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The following term was not found in PubMed: Sukhapunnapha
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THADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic beta-cell function and preserving beta-cell mass.
Zhang Y, Han S, Liu C, Zheng Y, Li H, Gao F, Bian Y, Liu X, Liu H, Hu S, Li Y, Chen ZJ, Zhao S, Zhao H. Zhang Y, et al. Nat Commun. 2023 Feb 23;14(1):1020. doi: 10.1038/s41467-023-36680-0. Nat Commun. 2023. PMID: 36823211 Free PMC article.
Here we report that THADA is strongly activated in human and mouse islets of T2DM. Both global and beta-cell-specific Thada-knockout mice exhibit improved glycemic control owing to enhanced beta-cell function and decreased beta-cell apoptosis. ...Collectively, our r …
Here we report that THADA is strongly activated in human and mouse islets of T2DM. Both global and beta-cell-specific Thada-kn …
Typhoid Fever.
Bhandari J, Thada PK, DeVos E. Bhandari J, et al. 2022 Aug 10. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2022 Aug 10. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 32491445 Free Books & Documents.
Neural Tube Disorders.
Bhandari J, Thada PK. Bhandari J, et al. 2023 Sep 15. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Sep 15. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 32310363 Free Books & Documents.
Thada Is Dispensable for Female Fertility in Mice.
Han S, Zhang Y, Zheng Y, Liu C, Jiang Y, Zhao S, Zhao H. Han S, et al. Front Endocrinol (Lausanne). 2022 Apr 5;13:787733. doi: 10.3389/fendo.2022.787733. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35480478 Free PMC article.
Genome-wide association studies (GWAS) have identified THADA as one of the susceptibility genes for polycystic ovary syndrome (PCOS). ...However, there was insufficient evidence to verify the effect of THADA in vivo on female reproductive system. In this study, we i …
Genome-wide association studies (GWAS) have identified THADA as one of the susceptibility genes for polycystic ovary syndrome (PCOS). …
THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy.
Li C, Chi H, Deng S, Wang H, Yao H, Wang Y, Chen D, Guo X, Fang JY, He F, Xu J. Li C, et al. J Immunother Cancer. 2021 Aug;9(8):e002443. doi: 10.1136/jitc-2021-002443. J Immunother Cancer. 2021. PMID: 34341130 Free PMC article.
In vitro experiments were performed to investigate the regulatory mechanism of PD-L1 by thyroid adenoma associated gene (THADA) using human colorectal cancer (CRC) cells. The prevalence of THADA was analyzed using CRC tissue microarrays by immunohistochemistry. ... …
In vitro experiments were performed to investigate the regulatory mechanism of PD-L1 by thyroid adenoma associated gene (THADA) using …
THADA gene polymorphism and prostate cancer risk: a meta-analysis.
Zhao F, Xu Y, Yang K, Liu M, Wei D, Zhang Y, Shi X, Yang F, Wang X, Liang S, Zhao C, Chen X, Sun L, Zhu X, Wang N, Hui J, Zhang Y, Zhu L, Yang Y, Tang L, Wang J, Yang Z. Zhao F, et al. Oncol Res Treat. 2014;37(3):106-10. doi: 10.1159/000360206. Epub 2014 Feb 21. Oncol Res Treat. 2014. PMID: 24685913 Review.
We investigated the association of rs1465618 in THADA with PCa in a Chinese population and carried out a meta-analysis in multiple populations, testing the relevance of this SNP for PCa risk. ...THADA gene polymorphisms may impact PCa susceptibility and progression. …
We investigated the association of rs1465618 in THADA with PCa in a Chinese population and carried out a meta-analysis in multiple po …
Scrofula.
Bhandari J, Thada PK. Bhandari J, et al. 2023 Apr 10. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. 2023 Apr 10. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 32491632 Free Books & Documents.
Asbestosis.
Bhandari J, Thada PK, Sedhai YR. Bhandari J, et al. 2022 Sep 19. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2022 Sep 19. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 32310445 Free Books & Documents.
Thermogenesis by THADA.
Chatterjee N, Perrimon N. Chatterjee N, et al. Dev Cell. 2017 Apr 10;41(1):1-2. doi: 10.1016/j.devcel.2017.03.021. Dev Cell. 2017. PMID: 28399393 Free PMC article.
THADA has been associated with cold adaptation and diabetes in humans, but the cellular and molecular basis of its function has been unknown. ...
THADA has been associated with cold adaptation and diabetes in humans, but the cellular and molecular basis of its function has been …
THADA Regulates the Organismal Balance between Energy Storage and Heat Production.
Moraru A, Cakan-Akdogan G, Strassburger K, Males M, Mueller S, Jabs M, Muelleder M, Frejno M, Braeckman BP, Ralser M, Teleman AA. Moraru A, et al. Dev Cell. 2017 Apr 10;41(1):72-81.e6. doi: 10.1016/j.devcel.2017.03.016. Dev Cell. 2017. PMID: 28399403 Free PMC article.
THADA binds the sarco/ER Ca(2+) ATPase (SERCA) and acts on it as an uncoupler. Reducing SERCA activity in THADA mutant flies rescues their obesity, pinpointing SERCA as a key effector of THADA function. ...
THADA binds the sarco/ER Ca(2+) ATPase (SERCA) and acts on it as an uncoupler. Reducing SERCA activity in THADA mutant flies r …
198 results