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Targeting interleukin-4 to the arthritic joint.
Spieler V, Ludwig MG, Dawson J, Tigani B, Littlewood-Evans A, Safina C, Ebersbach H, Seuwen K, Raschig M, Ter Mors B, Müller TD, Meinel L, Lühmann T. Spieler V, et al. J Control Release. 2020 Oct 10;326:172-180. doi: 10.1016/j.jconrel.2020.07.005. Epub 2020 Jul 10. J Control Release. 2020. PMID: 32653504
To increase its pharmacokinetic features, we engineered a murine IL4 conjugate by incorporating an unnatural amino acid through genetic code expansion to which PEG-folate, as a targeting moiety and PEG alone as control, were site-specifically bound. ...
To increase its pharmacokinetic features, we engineered a murine IL4 conjugate by incorporating an unnatural amino acid through genetic c …
A pan-cancer clinical platform to predict immunotherapy outcomes and prioritize immuno-oncology combinations in early-phase trials.
Hernando-Calvo A, Vila-Casadesús M, Bareche Y, Gonzalez-Medina A, Abbas-Aghababazadeh F, Lo Giacco D, Martin A, Saavedra O, Brana I, Vieito M, Fasani R, Stagg J, Mancuso F, Haibe-Kains B, Han M, Berche R, Pugh TJ, Mirallas O, Jimenez J, Gonzalez NS, Valverde C, Muñoz-Couselo E, Suarez C, Diez M, Élez E, Capdevila J, Oaknin A, Saura C, Macarulla T, Galceran JC, Felip E, Dienstmann R, Bedard PL, Nuciforo P, Seoane J, Tabernero J, Garralda E, Vivancos A. Hernando-Calvo A, et al. Med. 2023 Oct 13;4(10):710-727.e5. doi: 10.1016/j.medj.2023.07.006. Epub 2023 Aug 11. Med. 2023. PMID: 37572657 Free article.
Investigation of In-Field and Out-of-Field Radiation Quality With Microdosimetry and Its Impact on Relative Biological Effectiveness in Proton Therapy.
Missiaggia M, Cartechini G, Tommasino F, Scifoni E, La Tessa C. Missiaggia M, et al. Int J Radiat Oncol Biol Phys. 2023 Apr 1;115(5):1269-1282. doi: 10.1016/j.ijrobp.2022.11.037. Epub 2022 Nov 25. Int J Radiat Oncol Biol Phys. 2023. PMID: 36442542
This research also presents a first comprehensive benchmark of TOPAS code against in-field and out-of-field microdosimetric spectra of therapeutic protons. ...
This research also presents a first comprehensive benchmark of TOPAS code against in-field and out-of-field microdosimetric spectra o …
Automated extraction of radiation dose information for CT examinations.
Cook TS, Zimmerman S, Maidment AD, Kim W, Boonn WW. Cook TS, et al. J Am Coll Radiol. 2010 Nov;7(11):871-7. doi: 10.1016/j.jacr.2010.06.026. J Am Coll Radiol. 2010. PMID: 21040869
First, an open-source optical character recognition program processes each dose sheet and converts the information to American Standard Code for Information Interchange (ASCII) text. Each text file is parsed, and radiation dose information is extracted and stored in a data …
First, an open-source optical character recognition program processes each dose sheet and converts the information to American Standard C …