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Antithrombotic Therapy after Acute Coronary Syndrome or PCI in Atrial Fibrillation.
Lopes RD, Heizer G, Aronson R, Vora AN, Massaro T, Mehran R, Goodman SG, Windecker S, Darius H, Li J, Averkov O, Bahit MC, Berwanger O, Budaj A, Hijazi Z, Parkhomenko A, Sinnaeve P, Storey RF, Thiele H, Vinereanu D, Granger CB, Alexander JH; AUGUSTUS Investigators. Lopes RD, et al. N Engl J Med. 2019 Apr 18;380(16):1509-1524. doi: 10.1056/NEJMoa1817083. Epub 2019 Mar 17. N Engl J Med. 2019. PMID: 30883055 Free article. Clinical Trial.
Sequential Reagent Release from a Layered Tablet for Multistep Diagnostic Assays.
Li VYC, Udugama B, Kadhiresan P, Chan WCW. Li VYC, et al. Anal Chem. 2022 Dec 13;94(49):17102-17111. doi: 10.1021/acs.analchem.2c03315. Epub 2022 Dec 1. Anal Chem. 2022. PMID: 36454606
Diagnostic assays are commonly performed in multiple steps, where reagents are added at specific times and concentrations into a reaction chamber. The reagents require storage, preparation, and addition in the correct sequence and amount. ...
Diagnostic assays are commonly performed in multiple steps, where reagents are added at specific times and concentrations into a reaction …
The cardiac atria are chambers of active remodeling and dynamic collagen turnover during evolving heart failure.
Khan A, Moe GW, Nili N, Rezaei E, Eskandarian M, Butany J, Strauss BH. Khan A, et al. J Am Coll Cardiol. 2004 Jan 7;43(1):68-76. doi: 10.1016/j.jacc.2003.07.030. J Am Coll Cardiol. 2004. PMID: 14715186 Free article.
OBJECTIVES: The role of atrial myocytes and extracellular matrix (ECM) changes in atrial chamber remodeling was studied in a canine model of heart failure (HF). ...Atrial myocyte hypertrophy without evidence of apoptosis was also present in severe HF. CONCLUSIONS: There is …
OBJECTIVES: The role of atrial myocytes and extracellular matrix (ECM) changes in atrial chamber remodeling was studied in a canine m …
Overexpression of endothelial NO synthase induces angiogenesis in a co-culture model.
Babaei S, Stewart DJ. Babaei S, et al. Cardiovasc Res. 2002 Jul;55(1):190-200. doi: 10.1016/s0008-6363(02)00287-0. Cardiovasc Res. 2002. PMID: 12062722
Similarly, SMC(VEGF121) induced an angiogenic response (DI=14.2+/-3.8), which was also significantly inhibited by L-NAME (DI=5.9+/-1.8, P<0.05). In using the Boyden chamber model, SMC(eNOS), but not SMC(Cont) increased EC migration to a similar extent as SMC(VEGF121), a …
Similarly, SMC(VEGF121) induced an angiogenic response (DI=14.2+/-3.8), which was also significantly inhibited by L-NAME (DI=5.9+/-1.8, P< …
Type VIII collagen stimulates smooth muscle cell migration and matrix metalloproteinase synthesis after arterial injury.
Hou G, Mulholland D, Gronska MA, Bendeck MP. Hou G, et al. Am J Pathol. 2000 Feb;156(2):467-76. doi: 10.1016/S0002-9440(10)64751-7. Am J Pathol. 2000. PMID: 10666376 Free PMC article.
Type VIII collagen at 100 microgram/ml stimulated an 83-fold increase in the migration of SMCs in a chemotaxis chamber. Antibodies against beta1 integrin receptors prevented attachment and migration of SMCs. ...
Type VIII collagen at 100 microgram/ml stimulated an 83-fold increase in the migration of SMCs in a chemotaxis chamber. Antibodies ag …
A perlecan-inducing compound significantly inhibits smooth muscle cell function and in-stent intimal hyperplasia: novel insights into the diverse biological effects of perlecan.
Segev A, Nili N, Osherov AB, Qiang B, Wong AJ, Pillarisetti S, Strauss BH. Segev A, et al. EuroIntervention. 2010 May;6(1):134-40. EuroIntervention. 2010. PMID: 20542809
RUS3108 (1 microM) inhibited 3H-thymidine incorporation by >50%, which was completely reversed by a perlecan antibody. RUS3108 also inhibited SMC migration (Boyden chamber) and MMP-9 activity. In contrast, RUS3108 (100nM) modestly stimulated EC 3H-thymidine incorporatio …
RUS3108 (1 microM) inhibited 3H-thymidine incorporation by >50%, which was completely reversed by a perlecan antibody. RUS3108 also inhib …