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FK506-Binding Protein 2 Participates in Proinsulin Folding.
Hoefner C, Bryde TH, Pihl C, Tiedemann SN, Bresson SE, Hotiana HA, Khilji MS, Santos TD, Puglia M, Pisano P, Majewska M, Durzynska J, Klindt K, Klusek J, Perone MJ, Bucki R, Hägglund PM, Gourdon PE, Gotfryd K, Urbaniak E, Borowiak M, Wierer M, MacDonald PE, Mandrup-Poulsen T, Marzec MT. Hoefner C, et al. Among authors: bryde th. Biomolecules. 2023 Jan 11;13(1):152. doi: 10.3390/biom13010152. Biomolecules. 2023. PMID: 36671537 Free PMC article.
MCPIP1 is a novel link between diabetogenic conditions and impaired insulin secretory capacity.
Tyka K, Jörns A, Dunst A, Tang Y, Bryde TH, Mehmeti I, Walentinsson A, Marselli L, Cnop M, Tyrberg B, Marzec MT, Gurgul-Convey E. Tyka K, et al. Among authors: bryde th. Biochim Biophys Acta Mol Basis Dis. 2021 Oct 1;1867(10):166199. doi: 10.1016/j.bbadis.2021.166199. Epub 2021 Jun 16. Biochim Biophys Acta Mol Basis Dis. 2021. PMID: 34144091 Free article.
The inducible β5i proteasome subunit contributes to proinsulin degradation in GRP94-deficient β-cells and is overexpressed in type 2 diabetes pancreatic islets.
Khilji MS, Bresson SE, Verstappen D, Pihl C, Andersen PAK, Agergaard JB, Dahlby T, Bryde TH, Klindt K, Nielsen CK, Walentinsson A, Zivkovic D, Bousquet MP, Tyrberg B, Richardson SJ, Morgan NG, Mandrup-Poulsen T, Marzec MT. Khilji MS, et al. Among authors: bryde th. Am J Physiol Endocrinol Metab. 2020 Jun 1;318(6):E892-E900. doi: 10.1152/ajpendo.00372.2019. Epub 2020 Apr 7. Am J Physiol Endocrinol Metab. 2020. PMID: 32255680 Free article.
The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, low concentrations of interleukin 1 β.
Khilji MS, Verstappen D, Dahlby T, Burstein Prause MC, Pihl C, Bresson SE, Bryde TH, Keller Andersen PA, Klindt K, Zivkovic D, Bousquet-Dubouch MP, Tyrberg B, Mandrup-Poulsen T, Marzec MT. Khilji MS, et al. Among authors: bryde th. PLoS One. 2020 Feb 13;15(2):e0222432. doi: 10.1371/journal.pone.0222432. eCollection 2020. PLoS One. 2020. PMID: 32053590 Free PMC article.