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2000 1
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Page 1
Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes.
Husain M, Birkenfeld AL, Donsmark M, Dungan K, Eliaschewitz FG, Franco DR, Jeppesen OK, Lingvay I, Mosenzon O, Pedersen SD, Tack CJ, Thomsen M, Vilsbøll T, Warren ML, Bain SC; PIONEER 6 Investigators. Husain M, et al. N Engl J Med. 2019 Aug 29;381(9):841-851. doi: 10.1056/NEJMoa1901118. Epub 2019 Jun 11. N Engl J Med. 2019. PMID: 31185157 Clinical Trial.
Adipogenesis in thyroid eye disease.
Crisp M, Starkey KJ, Lane C, Ham J, Ludgate M. Crisp M, et al. Invest Ophthalmol Vis Sci. 2000 Oct;41(11):3249-55. Invest Ophthalmol Vis Sci. 2000. PMID: 11006210
PURPOSE: Adipogenesis contributes to the pathogenesis of thyroid eye disease (TED). Thyrotropin receptor (TSHR) transcripts are present in orbital fat. ...METHODS: Samples of fat were obtained from 18 TED-affected orbits and 4 normal orbits, and 9 were obtained from …
PURPOSE: Adipogenesis contributes to the pathogenesis of thyroid eye disease (TED). Thyrotropin receptor (TSHR) transcripts are prese …
Severely impaired terminal erythroid differentiation as an independent prognostic marker in myelodysplastic syndromes.
Ali AM, Huang Y, Pinheiro RF, Xue F, Hu J, Iverson N, Hoehn D, Coutinho D, Kayani J, Chernak B, Lane J, Hillyer C, Galili N, Jurcic J, Mohandas N, An X, Raza A. Ali AM, et al. Blood Adv. 2018 Jun 26;2(12):1393-1402. doi: 10.1182/bloodadvances.2018018440. Blood Adv. 2018. PMID: 29903708 Free PMC article.
Clinical and biologic associations were sought with presence or absence of TED and the specific stage of erythroid arrest. In 27% of MDS samples (56/205), there was no quantifiable TED documented by surface expression of integrin alpha-4 and band 3 by terminally dif …
Clinical and biologic associations were sought with presence or absence of TED and the specific stage of erythroid arrest. In 27% of …
Correction: Clinical utility of combinatorial pharmacogenomic testing in depression: A Canadian patient- and rater-blinded, randomized, controlled trial.
Tiwari AK, Zai CC, Altar CA, Tanner JA, Davies PE, Traxler P, Li J, Cogan ES, Kucera MT, Gugila A, Braganza N, Emmerson H, Zai G, Müller DJ, Levitan R, Kloiber S, Daskalakis ZJ, Frey BN, Bowen JM, Tarride JE, Tytus R, Chandrasena R, Voudouris N, Taylor VH, Tempier R, Sharma V, Vasudev A, Dzongowski P, Pliamm L, Greenspoon T, Dechairo BM, Kennedy JL. Tiwari AK, et al. Transl Psychiatry. 2022 May 30;12(1):214. doi: 10.1038/s41398-022-01963-5. Transl Psychiatry. 2022. PMID: 35637185 Free PMC article. No abstract available.
Domain structure of human complement C4b extends with increasing NaCl concentration: implications for its regulatory mechanism.
Fung KW, Wright DW, Gor J, Swann MJ, Perkins SJ. Fung KW, et al. Biochem J. 2016 Dec 1;473(23):4473-4491. doi: 10.1042/BCJ20160744. Epub 2016 Oct 13. Biochem J. 2016. PMID: 27738201
In the C4b crystal structure, TED forms an Arg(104)-Glu(1032) salt bridge to tether its neighbouring macroglobulin (MG1) domain. ...Analytical ultracentrifugation showed that the sedimentation coefficient s(20,w) of monomeric C4b of 8.41 S in 50 mM NaCl buffe …
In the C4b crystal structure, TED forms an Arg(104)-Glu(1032) salt bridge to tether its neighbouring macroglobulin (MG1) domain. ...A …
Clinical utility of combinatorial pharmacogenomic testing in depression: A Canadian patient- and rater-blinded, randomized, controlled trial.
Tiwari AK, Zai CC, Altar CA, Tanner JA, Davies PE, Traxler P, Li J, Cogan ES, Kucera MT, Gugila A, Braganza N, Emmerson H, Zai G, Müller DJ, Levitan R, Kloiber S, Daskalakis ZJ, Frey BN, Bowen JM, Tarride JE, Tytus R, Chandrasena R, Voudouris N, Taylor VH, Tempier R, Sharma V, Vasudev A, Dzongowski P, Pliamm L, Greenspoon T, Dechairo BM, Kennedy JL. Tiwari AK, et al. Transl Psychiatry. 2022 Mar 14;12(1):101. doi: 10.1038/s41398-022-01847-8. Transl Psychiatry. 2022. PMID: 35288545 Free PMC article. Clinical Trial.
However, in a large, randomized-controlled trial (RCT) in the U.S. ("GUIDED"), significant improvements in response and remission rates were observed in patients who received treatment guided by combinatorial pharmacogenomic testing, compared to treatment-as-usual (TAU). . …
However, in a large, randomized-controlled trial (RCT) in the U.S. ("GUIDED"), significant improvements in response and remission rat …
Rapid, non-contact multifocal visual assessment in multiple sclerosis.
Maddess T, van Kleef JP, Rohan EMF, Carle CF, Baird-Gunning J, Rai BB, Bruestle A, Lane J, Lueck CJ. Maddess T, et al. Neurol Sci. 2023 Jan;44(1):273-279. doi: 10.1007/s10072-022-06387-z. Epub 2022 Sep 13. Neurol Sci. 2023. PMID: 36098887 Free PMC article.
METHODS: One high-spatial-resolution mfPOP method, P129, and two rapid medium-resolution methods, W12 and W20, were tested on 44 PwMS and controls. W12 and W20 took 82 s to test both visual fields concurrently, providing response delay and sensitivity at each field locatio …
METHODS: One high-spatial-resolution mfPOP method, P129, and two rapid medium-resolution methods, W12 and W20, were tested on 44 PwMS and co …
Differentiation of reactive-like astrocytes cultured on nanofibrillar and comparative culture surfaces.
Tiryaki VM, Ayres VM, Ahmed I, Shreiber DI. Tiryaki VM, et al. Nanomedicine (Lond). 2015 Mar;10(4):529-45. doi: 10.2217/nnm.14.33. Epub 2014 Jul 2. Nanomedicine (Lond). 2015. PMID: 24985141 Free article.
RESULTS & CONCLUSION: Nanofibrillar scaffold properties were shown to reduce immunoreactivity responses while poly-L-lysine-functionalized Aclar (Ted Pella Inc., CA, USA) properties were shown to induce responses reminiscent of glial scar formation. ...
RESULTS & CONCLUSION: Nanofibrillar scaffold properties were shown to reduce immunoreactivity responses while poly-L-lysine-functionaliz …
Effect of inhalation profile and throat geometry on predicted lung deposition of budesonide and formoterol (BF) in COPD: An in-vitro comparison of Spiromax with Turbuhaler.
Chrystyn H, Safioti G, Keegstra JR, Gopalan G. Chrystyn H, et al. Int J Pharm. 2015 Aug 1;491(1-2):268-76. doi: 10.1016/j.ijpharm.2015.05.076. Epub 2015 Jun 1. Int J Pharm. 2015. PMID: 26043823 Free article.
Combining the dose emission results for the three throat sizes, the mean (SD) budesonide fine-particle dose (FPD) from budesonide-formoterol Spiromax 320/9 mug was 78.91 (20.18), 79.91 (15.36) and 75.10 (19.91)mug and the total emitted dose (TED) of budesonide was 263.69 ( …
Combining the dose emission results for the three throat sizes, the mean (SD) budesonide fine-particle dose (FPD) from budesonide-formoterol …