Anticancer potential of limonoids from Swietenia macrophylla: Genotoxic, antiproliferative and proapoptotic effects towards human colorectal cancer.
Pinto LC, Mesquita FP, Barreto LH, Souza PFN, Ramos INF, Pinto AVU, Soares BM, da Silva MN, Burbano RMR, Montenegro RC.
Pinto LC, et al.
Life Sci. 2021 Nov 15;285:119949. doi: 10.1016/j.lfs.2021.119949. Epub 2021 Sep 20.
Life Sci. 2021.
PMID: 34543640
The antiproliferative effect of L1 was confirmed in colorectal cancer cells by clonogenic assay, inducing G2/M arrest, apoptosis, and DNA damage in cancer-type cells. SIGNIFICANCE: L1 reduced BCL2 and increased ATM, CHK2, TP53, ARF, CDK1, CDKN1A, and CASP3 in the colorecta …
The antiproliferative effect of L1 was confirmed in colorectal cancer cells by clonogenic assay, inducing G2/M arrest, apoptosis, and …