Supramolecular architecture of betulin diacetate complexes with arabinogalactan from Larix sibirica

Mikhail A Mikhailenko; Tatyana P Shakhtshneider; Ilia V Eltsov; Alexander S Kozlov; Svetlana A Kuznetsova; Аnton А Karacharov; Vladimir V Boldyrev

doi:10.1016/j.carbpol.2015.11.047

Supramolecular architecture of betulin diacetate complexes with arabinogalactan from Larix sibirica

Carbohydr Polym. 2016 Mar 15:138:1-7. doi: 10.1016/j.carbpol.2015.11.047. Epub 2015 Nov 21.

Authors

Mikhail A Mikhailenko¹, Tatyana P Shakhtshneider², Ilia V Eltsov³, Alexander S Kozlov⁴, Svetlana A Kuznetsova⁵, Аnton А Karacharov⁵, Vladimir V Boldyrev⁶

Affiliations

¹ Institute of Solid State Chemistry and Mechanochemistry SB RAS, Kutateladze str., 18, Novosibirsk 630128, Russia.
² Institute of Solid State Chemistry and Mechanochemistry SB RAS, Kutateladze str., 18, Novosibirsk 630128, Russia; Novosibirsk State University, Pirogova str., 2, Novosibirsk 630090, Russia. Electronic address: shah@solid.nsc.ru.
³ Novosibirsk State University, Pirogova str., 2, Novosibirsk 630090, Russia.
⁴ Institute of Chemical Kinetics and Combustion SB RAS, Institutskaya str., 3, Novosibirsk 630090, Russia.
⁵ Institute of Chemistry and Chemical Technology SB RAS, Academgorodok, 50/24, Krasnoyarsk 660036, Russia; Siberian Federal University, Svobodny pr., 79/10, Krasnoyarsk 660041, Russia.
⁶ Institute of Solid State Chemistry and Mechanochemistry SB RAS, Kutateladze str., 18, Novosibirsk 630128, Russia; Novosibirsk State University, Pirogova str., 2, Novosibirsk 630090, Russia.

PMID: 26794731
DOI: 10.1016/j.carbpol.2015.11.047

Abstract

Supramolecular ensembles of arabinogalactan (AG) and its complexes with betulin diacetate (BDA) were studied in water and dimethyl sulfoxide (DMSO) using ablation, induced by submillimeter radiation from the free electron laser. Solutions of 1wt% AG resulted in formation of aerosol particles with a maximum size of 60-70nm. In contrast, with DMSO as the solvent, the majority of particles were significantly smaller. Nevertheless, the addition of water shifted the particle size distribution to a larger size, suggesting the cross-linking of AG chains due to hydrogen bonding through water molecules. The ensembles of molecules were larger in solutions of the AG-BDA complex as compared to pure AG aqueous solution, and the distribution was narrow. The role of side chain interactions in the formation of AG-BDA complexes in aqueous solutions was confirmed by NMR.

Keywords: Arabinogalactan; Arabinogalactan–betulin diacetate complex; Betulin diacetate; NMR; Polymer associates; THz laser ablation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Dimethyl Sulfoxide / chemistry
Galactans / chemistry*
Hydrogen Bonding
Larix / metabolism*
Magnetic Resonance Spectroscopy
Microscopy, Atomic Force
Particle Size
Triterpenes / chemistry*
Water / chemistry

Substances

Galactans
Triterpenes
Water
betulin
arabinogalactan
Dimethyl Sulfoxide