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Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan.
Munkuev AA, Dyrkheeva NS, Kornienko TE, Ilina ES, Ivankin DI, Suslov EV, Korchagina DV, Gatilov YV, Zakharenko AL, Malakhova AA, Reynisson J, Volcho KP, Salakhutdinov NF, Lavrik OI. Munkuev AA, et al. Among authors: kornienko te. Molecules. 2022 May 24;27(11):3374. doi: 10.3390/molecules27113374. Molecules. 2022. PMID: 35684313 Free PMC article.
The Lipophilic Purine Nucleoside-Tdp1 Inhibitor-Enhances DNA Damage Induced by Topotecan In Vitro and Potentiates the Antitumor Effect of Topotecan In Vivo.
Chernyshova IA, Zakharenko AL, Kurochkin NN, Dyrkheeva NS, Kornienko TE, Popova NA, Nikolin VP, Ilina ES, Zharkov TD, Kupryushkin MS, Oslovsky VE, Drenichev MS, Lavrik OI. Chernyshova IA, et al. Among authors: kornienko te. Molecules. 2022 Dec 31;28(1):323. doi: 10.3390/molecules28010323. Molecules. 2022. PMID: 36615517 Free PMC article.
Pharmacokinetic study of Tdp1 inhibitor resulted in a significant increase in antitumor effect in the treatment of Lewis lung carcinoma in mice by its combination with topotecan.
Okhina AA, Kornienko TE, Rogachev AD, Luzina OA, Popova NA, Nikolin VP, Zakharenko AL, Dyrkheeva NS, Pokrovsky AG, Salakhutdinov NF, Lavrik OI. Okhina AA, et al. Among authors: kornienko te. J Pharm Biomed Anal. 2023 Nov 30;236:115731. doi: 10.1016/j.jpba.2023.115731. Epub 2023 Sep 18. J Pharm Biomed Anal. 2023. PMID: 37741072
New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1.
Dyrkheeva NS, Filimonov AS, Luzina OA, Orlova KA, Chernyshova IA, Kornienko TE, Malakhova AA, Medvedev SP, Zakharenko AL, Ilina ES, Anarbaev RO, Naumenko KN, Klabenkova KV, Burakova EA, Stetsenko DA, Zakian SM, Salakhutdinov NF, Lavrik OI. Dyrkheeva NS, et al. Among authors: kornienko te. Int J Mol Sci. 2021 Oct 20;22(21):11336. doi: 10.3390/ijms222111336. Int J Mol Sci. 2021. PMID: 34768766 Free PMC article.