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Conjugates of Tacrine with Salicylamide as Promising Multitarget Agents for Alzheimer's Disease.
Grishchenko MV, Makhaeva GF, Burgart YV, Rudakova EV, Boltneva NP, Kovaleva NV, Serebryakova OG, Lushchekina SV, Astakhova TY, Zhilina EF, Shchegolkov EV, Richardson RJ, Saloutin VI. Grishchenko MV, et al. Among authors: astakhova ty. ChemMedChem. 2022 May 18;17(10):e202200080. doi: 10.1002/cmdc.202200080. Epub 2022 Mar 23. ChemMedChem. 2022. PMID: 35322571 Free PMC article.
New Multifunctional Agents for Potential Alzheimer's Disease Treatment Based on Tacrine Conjugates with 2-Arylhydrazinylidene-1,3-Diketones.
Elkina NA, Grishchenko MV, Shchegolkov EV, Makhaeva GF, Kovaleva NV, Rudakova EV, Boltneva NP, Lushchekina SV, Astakhova TY, Radchenko EV, Palyulin VA, Zhilina EF, Perminova AN, Lapshin LS, Burgart YV, Saloutin VI, Richardson RJ. Elkina NA, et al. Among authors: astakhova ty. Biomolecules. 2022 Oct 24;12(11):1551. doi: 10.3390/biom12111551. Biomolecules. 2022. PMID: 36358901 Free PMC article.
Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N-Functionalization Determines the Multitarget Anti-Alzheimer's Activity Profile.
Makhaeva GF, Kovaleva NV, Boltneva NP, Rudakova EV, Lushchekina SV, Astakhova TY, Serkov IV, Proshin AN, Radchenko EV, Palyulin VA, Korabecny J, Soukup O, Bachurin SO, Richardson RJ. Makhaeva GF, et al. Molecules. 2022 Feb 4;27(3):1060. doi: 10.3390/molecules27031060. Molecules. 2022. PMID: 35164325 Free PMC article.
Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer's Disease.
Makhaeva GF, Kovaleva NV, Rudakova EV, Boltneva NP, Grishchenko MV, Lushchekina SV, Astakhova TY, Serebryakova OG, Timokhina EN, Zhilina EF, Shchegolkov EV, Ulitko MV, Radchenko EV, Palyulin VA, Burgart YV, Saloutin VI, Bachurin SO, Richardson RJ. Makhaeva GF, et al. Among authors: astakhova ty. Int J Mol Sci. 2023 Jan 24;24(3):2285. doi: 10.3390/ijms24032285. Int J Mol Sci. 2023. PMID: 36768608 Free PMC article.
Derivatives of 9-phosphorylated acridine as butyrylcholinesterase inhibitors with antioxidant activity and the ability to inhibit β-amyloid self-aggregation: potential therapeutic agents for Alzheimer's disease.
Makhaeva GF, Kovaleva NV, Rudakova EV, Boltneva NP, Lushchekina SV, Astakhova TY, Timokhina EN, Serebryakova OG, Shchepochkin AV, Averkov MA, Utepova IA, Demina NS, Radchenko EV, Palyulin VA, Fisenko VP, Bachurin SO, Chupakhin ON, Charushin VN, Richardson RJ. Makhaeva GF, et al. Front Pharmacol. 2023 Aug 9;14:1219980. doi: 10.3389/fphar.2023.1219980. eCollection 2023. Front Pharmacol. 2023. PMID: 37654616 Free PMC article.
Combining Experimental and Computational Methods to Produce Conjugates of Anticholinesterase and Antioxidant Pharmacophores with Linker Chemistries Affecting Biological Activities Related to Treatment of Alzheimer's Disease.
Makhaeva GF, Kovaleva NV, Rudakova EV, Boltneva NP, Lushchekina SV, Astakhova TY, Timokhina EN, Serkov IV, Proshin AN, Soldatova YV, Poletaeva DA, Faingold II, Mumyatova VA, Terentiev AA, Radchenko EV, Palyulin VA, Bachurin SO, Richardson RJ. Makhaeva GF, et al. Among authors: astakhova ty. Molecules. 2024 Jan 9;29(2):321. doi: 10.3390/molecules29020321. Molecules. 2024. PMID: 38257233 Free PMC article.
New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer's Disease Treatment.
Makhaeva GF, Kovaleva NV, Boltneva NP, Lushchekina SV, Astakhova TY, Rudakova EV, Proshin AN, Serkov IV, Radchenko EV, Palyulin VA, Bachurin SO, Richardson RJ. Makhaeva GF, et al. Molecules. 2020 Aug 27;25(17):3915. doi: 10.3390/molecules25173915. Molecules. 2020. PMID: 32867324 Free PMC article.