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The following term was not found in PubMed: Wongvorachan
Page 1
GADD45A binds R-loops and recruits TET1 to CpG island promoters.
Arab K, Karaulanov E, Musheev M, Trnka P, Schäfer A, Grummt I, Niehrs C. Arab K, et al. Nat Genet. 2019 Feb;51(2):217-223. doi: 10.1038/s41588-018-0306-6. Epub 2019 Jan 7. Nat Genet. 2019. PMID: 30617255 Free PMC article.
Studying the tumor suppressor TCF21 (ref. (9)), we find that antisense long noncoding (lncRNA) TARID (TCF21 antisense RNA inducing promoter demethylation) forms an R-loop at the TCF21 promoter. Binding of GADD45A to the R-loop triggers local DNA demethylation and TCF21 exp …
Studying the tumor suppressor TCF21 (ref. (9)), we find that antisense long noncoding (lncRNA) TARID (TCF21 antisense RNA inducing pr …
Intrapericardial long non-coding RNA-Tcf21 antisense RNA inducing demethylation administration promotes cardiac repair.
Zhu D, Liu S, Huang K, Li J, Mei X, Li Z, Cheng K. Zhu D, et al. Eur Heart J. 2023 May 14;44(19):1748-1760. doi: 10.1093/eurheartj/ehad114. Eur Heart J. 2023. PMID: 36916305 Free PMC article.
Formulated lncRNA-TARID-laden lipid nanoparticles up-regulated Tcf21 expression in epicardium-derived cells and improved cardiac function and histology in mouse and porcine models of myocardial infarction. CONCLUSION: This study identified Tcf21 as a critical target for im …
Formulated lncRNA-TARID-laden lipid nanoparticles up-regulated Tcf21 expression in epicardium-derived cells and improved cardiac func …
LncRNA TARID induces cell proliferation through cell cycle pathway associated with coronary artery disease.
Cheng Z, Zhang Y, Zhuo Y, Fan J, Xu Y, Li M, Chen H, Zhou L. Cheng Z, et al. Mol Biol Rep. 2022 Jun;49(6):4573-4581. doi: 10.1007/s11033-022-07304-5. Epub 2022 Mar 18. Mol Biol Rep. 2022. PMID: 35304681
BACKGROUND/AIM: Long non-coding RNA TARID (lncRNA TARID) can activate the tumor suppressor TCF21 in tumorigenesis by inducing promoter demethylation. However, the impact on lncRNA TARID and its variants of coronary artery disease (CAD) are poorly understood. …
BACKGROUND/AIM: Long non-coding RNA TARID (lncRNA TARID) can activate the tumor suppressor TCF21 in tumorigenesis by inducing …
The long noncoding RNA TARID regulates the CXCL3/ERK/MAPK pathway in trophoblasts and is associated with preeclampsia.
Liao L, Liu M, Gao Y, Wei X, Yin Y, Gao L, Zhou R. Liao L, et al. Reprod Biol Endocrinol. 2022 Nov 19;20(1):159. doi: 10.1186/s12958-022-01036-8. Reprod Biol Endocrinol. 2022. PMID: 36401313 Free PMC article.
Furthermore, we verified the effect of TARID on the biological behavior of trophoblasts and performed UID mRNA-seq to identify the effectors downstream of TARID. ...CONCLUSIONS: Overall, these findings suggested that TARID may be a therapeutic target for PE t …
Furthermore, we verified the effect of TARID on the biological behavior of trophoblasts and performed UID mRNA-seq to identify the ef …
Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A.
Arab K, Park YJ, Lindroth AM, Schäfer A, Oakes C, Weichenhan D, Lukanova A, Lundin E, Risch A, Meister M, Dienemann H, Dyckhoff G, Herold-Mende C, Grummt I, Niehrs C, Plass C. Arab K, et al. Mol Cell. 2014 Aug 21;55(4):604-14. doi: 10.1016/j.molcel.2014.06.031. Epub 2014 Jul 31. Mol Cell. 2014. PMID: 25087872 Free article.
How demethylating enzymes are targeted to specific genomic loci remains largely unknown. We show that an antisense lncRNA, termed TARID (for TCF21 antisense RNA inducing demethylation), activates TCF21 expression by inducing promoter demethylation. TARID interacts w …
How demethylating enzymes are targeted to specific genomic loci remains largely unknown. We show that an antisense lncRNA, termed TARID …
TCF21 hypermethylation in genetically quiescent clear cell sarcoma of the kidney.
Gooskens SL, Gadd S, Guidry Auvil JM, Gerhard DS, Khan J, Patidar R, Meerzaman D, Chen QR, Hsu CH, Yan C, Nguyen C, Hu Y, Mullighan CG, Ma J, Jennings LJ, de Krijger RR, van den Heuvel-Eibrink MM, Smith MA, Ross N, Gastier-Foster JM, Perlman EJ. Gooskens SL, et al. Oncotarget. 2015 Jun 30;6(18):15828-41. doi: 10.18632/oncotarget.4682. Oncotarget. 2015. PMID: 26158413 Free PMC article.
TCF21 hypermethylation and decreased TARID expression were validated in an independent set of CCSK tumor samples. The presence of significant hypermethylation of TCF21, a transcription factor known to be active early in renal development, supports the hypothesis that hyper …
TCF21 hypermethylation and decreased TARID expression were validated in an independent set of CCSK tumor samples. The presence of sig …
A tumor mutational burden-derived immune computational framework selects sensitive immunotherapy/chemotherapy for lung adenocarcinoma populations with different prognoses.
Zhang W, Wei C, Huang F, Huang W, Xu X, Zhu X. Zhang W, et al. Front Oncol. 2023 Jun 30;13:1104137. doi: 10.3389/fonc.2023.1104137. eCollection 2023. Front Oncol. 2023. PMID: 37456238 Free PMC article.
RESULTS: The TILPI computing framework was based on the expression of TMB-derived immune lncRNA signature (TILncSig), which consisted of AC091057.1, AC112721.1, AC114763.1, AC129492.1, LINC00592, and TARID. TILPI divided all LUAD patients into two populations with differen …
RESULTS: The TILPI computing framework was based on the expression of TMB-derived immune lncRNA signature (TILncSig), which consisted of AC0 …
Exploration of potential therapeutic targets for stroke based on the GEO database.
Ma LZ, Dong LW, Zhu J, Yu JS, Deng QL. Ma LZ, et al. Ann Transl Med. 2021 Dec;9(24):1759. doi: 10.21037/atm-21-5815. Ann Transl Med. 2021. PMID: 35071453 Free PMC article.
According to |log2FC| values from highest to lowest, the top 10 lncRNAs with the most significant differences were selected. The upregulated lncRNAs were LINC02334, TARID, MRGPRF-AS1, CAI2, LINC00189, TUG1, and RNF5P1. The downregulated lncRNAs included AC005180.2, ADAMTS9 …
According to |log2FC| values from highest to lowest, the top 10 lncRNAs with the most significant differences were selected. The upregulated …
Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.
Liang J, Le TH, Edwards DRV, Tayo BO, Gaulton KJ, Smith JA, Lu Y, Jensen RA, Chen G, Yanek LR, Schwander K, Tajuddin SM, Sofer T, Kim W, Kayima J, McKenzie CA, Fox E, Nalls MA, Young JH, Sun YV, Lane JM, Cechova S, Zhou J, Tang H, Fornage M, Musani SK, Wang H, Lee J, Adeyemo A, Dreisbach AW, Forrester T, Chu PL, Cappola A, Evans MK, Morrison AC, Martin LW, Wiggins KL, Hui Q, Zhao W, Jackson RD, Ware EB, Faul JD, Reiner AP, Bray M, Denny JC, Mosley TH, Palmas W, Guo X, Papanicolaou GJ, Penman AD, Polak JF, Rice K, Taylor KD, Boerwinkle E, Bottinger EP, Liu K, Risch N, Hunt SC, Kooperberg C, Zonderman AB, Laurie CC, Becker DM, Cai J, Loos RJF, Psaty BM, Weir DR, Kardia SLR, Arnett DK, Won S, Edwards TL, Redline S, Cooper RS, Rao DC, Rotter JI, Rotimi C, Levy D, Chakravarti A, Zhu X, Franceschini N. Liang J, et al. PLoS Genet. 2017 May 12;13(5):e1006728. doi: 10.1371/journal.pgen.1006728. eCollection 2017 May. PLoS Genet. 2017. PMID: 28498854 Free PMC article.

These analyses identified nine loci with eleven independent variants which reached genome-wide significance (P < 1.2510-8) for either systolic and diastolic blood pressure, hypertension, or for combined traits. Single-trait analyses identified two loci (TARID/TCF21 and

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These analyses identified nine loci with eleven independent variants which reached genome-wide significance (P < 1.2510-8) for either sys

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