Analysis of latent CHIKV dynamics models with general incidence rate and time delays

J Biol Dyn. 2018 Dec;12(1):700-730. doi: 10.1080/17513758.2018.1503349.

Abstract

In this paper, we study the stability analysis of latent Chikungunya virus (CHIKV) dynamics models. The incidence rate between the CHIKV and the uninfected monocytes is modelled by a general nonlinear function which satisfies a set of conditions. The model is incorporated by intracellular discrete or distributed time delays. Using the method of Lyapunov function, we established the global stability of the steady states of the models. The theoretical results are confirmed by numerical simulations.

Keywords: Chikungunya virus infection; Global stability; Lyapunov function; general incidence rate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • B-Lymphocytes / virology
  • Chikungunya Fever / epidemiology*
  • Chikungunya Fever / virology*
  • Chikungunya virus / physiology*
  • Computer Simulation
  • Humans
  • Incidence
  • Models, Biological*
  • Monocytes / virology
  • Numerical Analysis, Computer-Assisted
  • Time Factors
  • Virion / metabolism
  • Virus Latency*