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Discovery and Evaluation of C6-Substituted Pyrazolopyrimidine-Based Bisphosphonate Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase and Evaluation of Their Antitumor Efficacy in Multiple Myeloma, Pancreatic Ductal Adenocarcinoma, and Colorectal Cancer.
Boutin R, Lee HF, Guan TL, Nguyen TT, Huang XF, Waller DD, Lu J, Christine Chio II, Michel RP, Sebag M, Tsantrizos YS. Boutin R, et al. J Med Chem. 2023 Dec 14;66(23):15776-15800. doi: 10.1021/acs.jmedchem.3c01271. Epub 2023 Nov 20. J Med Chem. 2023. PMID: 37982711 Free PMC article.
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