Biosynthetic studies on water-soluble derivative 5c (DTX5c)

Tamara S Vilches; Manuel Norte; Antonio Hernández Daranas; José J Fernández

doi:10.3390/md10102234

Biosynthetic studies on water-soluble derivative 5c (DTX5c)

Mar Drugs. 2012 Oct;10(10):2234-2245. doi: 10.3390/md10102234. Epub 2012 Oct 12.

Authors

Tamara S Vilches¹, Manuel Norte^{1

2}, Antonio Hernández Daranas^{1

3}, José J Fernández^{1

2}

Affiliations

¹ University Institute for Bio-Organic Chemistry "Antonio González", University of La Laguna, Av. Astrofísico Francisco Sánchez 2, La Laguna 38206, Spain.
² Department of Organic Chemistry, Faculty of Pharmacy, University of La Laguna, Av. Astrofísico Francisco Sánchez s/n, La Laguna 38206, Spain.
³ Department of Chemical Engineering and Pharmaceutical Technology, Faculty of Pharmacy, University of La Laguna, Av. Astrofísico Francisco Sánchez s/n, La Laguna 38206, Spain.

Abstract

The dinoflagellate Prorocentrum belizeanum is responsible for the production of several toxins involved in the red tide phenomenon known as Diarrhetic Shellfish Poisoning (DSP). In this paper we report on the biosynthetic origin of an okadaic acid water-soluble ester derivative, DTX5c, on the basis of the spectroscopical analysis of ¹³C enriched samples obtained by addition of labelled sodium [l-¹³C], [2-¹³C] acetate to artificial cultures of this dinoflagellate.

Keywords: DSP; biosynthesis; marine polyether; marine toxin; polyketide.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Dinoflagellida / metabolism*
Molecular Structure
Okadaic Acid / analogs & derivatives*
Okadaic Acid / chemistry
Okadaic Acid / metabolism

Substances

DTX5c compound
Okadaic Acid