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Page 1
PERK Pathway and Neurodegenerative Disease: To Inhibit or to Activate?
Biomolecules. 2021 Feb 26;11(3):354. doi: 10.3390/biom11030354.
Biomolecules. 2021.
PMID: 33652720
Free PMC article.
Review.
Protein Misfolding and ER Stress in Huntington's Disease.
Shacham T, Sharma N, Lederkremer GZ.
Shacham T, et al.
Front Mol Biosci. 2019 Apr 3;6:20. doi: 10.3389/fmolb.2019.00020. eCollection 2019.
Front Mol Biosci. 2019.
PMID: 31001537
Free PMC article.
Review.
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A novel specific PERK activator reduces toxicity and extends survival in Huntington's disease models.
Ganz J, Shacham T, Kramer M, Shenkman M, Eiger H, Weinberg N, Iancovici O, Roy S, Simhaev L, Da'adoosh B, Engel H, Perets N, Barhum Y, Portnoy M, Offen D, Lederkremer GZ.
Ganz J, et al. Among authors: shacham t.
Sci Rep. 2020 Apr 23;10(1):6875. doi: 10.1038/s41598-020-63899-4.
Sci Rep. 2020.
PMID: 32327686
Free PMC article.
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Efficacy of therapy by MK-28 PERK activation in the Huntington's disease R6/2 mouse model.
Shacham T, Offen D, Lederkremer GZ.
Shacham T, et al.
Neurotherapeutics. 2024 Mar;21(2):e00335. doi: 10.1016/j.neurot.2024.e00335. Epub 2024 Feb 16.
Neurotherapeutics. 2024.
PMID: 38368172
Free PMC article.
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