Abstract
We have developed practical thiol surrogates and arylthiol protective groups for the Suzuki-Miyaura reaction. 2-Ethylhexyl-3-mercaptopropionate and 4-(2'-mercaptoethyl)pyridine were shown to be not only good thiol surrogates but also good protective groups for thiol. We have demonstrated toleration of these protective groups under aqueous Suzuki-Miyaura conditions.
MeSH terms
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3-Mercaptopropionic Acid / analogs & derivatives*
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3-Mercaptopropionic Acid / chemical synthesis
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3-Mercaptopropionic Acid / chemistry
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Pyridines / chemical synthesis
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Pyridines / chemistry*
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Sulfhydryl Compounds / chemical synthesis
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Sulfhydryl Compounds / chemistry*
Substances
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2-ethylhexyl-3-mercaptopropionic acid
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4-(2'-mercaptoethyl)pyridine
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Pyridines
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Sulfhydryl Compounds
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3-Mercaptopropionic Acid