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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1936 1
1948 2
1949 1
1950 3
1951 2
1953 3
1954 3
1955 5
1956 2
1957 4
1958 6
1963 1
1964 7
1965 2
1966 3
1967 5
1968 5
1969 1
1970 7
1971 6
1972 11
1973 8
1974 4
1975 6
1976 3
1977 9
1978 3
1979 3
1980 6
1981 4
1983 1
1984 4
1985 1
1986 5
1987 7
1988 7
1989 4
1990 13
1991 5
1992 5
1993 15
1994 13
1995 5
1996 16
1997 10
1998 11
1999 12
2000 18
2001 16
2002 16
2003 20
2004 16
2005 24
2006 37
2007 31
2008 34
2009 29
2010 30
2011 36
2012 45
2013 50
2014 46
2015 53
2016 53
2017 48
2018 46
2019 28
2020 22
2021 20
2022 20
2023 20
2024 5

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931 results

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The following term was not found in PubMed: Mohammadat
Page 1
Universal definition of myocardial infarction.
Thygesen K, Alpert JS, White HD; Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Thygesen K, et al. J Am Coll Cardiol. 2007 Nov 27;50(22):2173-95. doi: 10.1016/j.jacc.2007.09.011. J Am Coll Cardiol. 2007. PMID: 18036459 Free article. No abstract available.
Intracellular Toxic AGEs (TAGE) Triggers Numerous Types of Cell Damage.
Takeuchi M, Sakasai-Sakai A, Takata T, Takino JI, Koriyama Y, Kikuchi C, Furukawa A, Nagamine K, Hori T, Matsunaga T. Takeuchi M, et al. Biomolecules. 2021 Mar 5;11(3):387. doi: 10.3390/biom11030387. Biomolecules. 2021. PMID: 33808036 Free PMC article. Review.
We demonstrated that the intracellular accumulation of TAGE triggered numerous cellular disorders, and also that TAGE leaked into the extracellular space, thereby increasing extracellular TAGE levels in circulating fluids. ...In this review, we discuss the re …
We demonstrated that the intracellular accumulation of TAGE triggered numerous cellular disorders, and also that TAGE leaked i …
Effects of Toxic AGEs (TAGE) on Human Health.
Takeuchi M, Sakasai-Sakai A, Takata T, Takino JI, Koriyama Y. Takeuchi M, et al. Cells. 2022 Jul 12;11(14):2178. doi: 10.3390/cells11142178. Cells. 2022. PMID: 35883620 Free PMC article. Review.
Elevated circulating levels of TAGE have been detected in non-diabetics and diabetics, indicating a strong relationship between the generation/accumulation of TAGE in vivo and the onset and progression of LSRD. We herein outline current findings on "TAGE as a …
Elevated circulating levels of TAGE have been detected in non-diabetics and diabetics, indicating a strong relationship between the g …
The Relevance of Toxic AGEs (TAGE) Cytotoxicity to NASH Pathogenesis: A Mini-Review.
Sakasai-Sakai A, Takata T, Takino JI, Takeuchi M. Sakasai-Sakai A, et al. Nutrients. 2019 Feb 22;11(2):462. doi: 10.3390/nu11020462. Nutrients. 2019. PMID: 30813302 Free PMC article. Review.
Furthermore, the TAGE precursor, GA, causes cell damage through protein dysfunctions by TAGE modifications and induces necrotic-type hepatocyte death. Intracellular TAGE may leak outside of necrotic-type cells. Extracellular TAGE then induce inflammato …
Furthermore, the TAGE precursor, GA, causes cell damage through protein dysfunctions by TAGE modifications and induces necroti …
Involvement of Intracellular TAGE and the TAGE-RAGE-ROS Axis in the Onset and Progression of NAFLD/NASH.
Sakasai-Sakai A, Takeda K, Takeuchi M. Sakasai-Sakai A, et al. Antioxidants (Basel). 2023 Mar 19;12(3):748. doi: 10.3390/antiox12030748. Antioxidants (Basel). 2023. PMID: 36978995 Free PMC article. Review.
This review describes the relationships between intracellular TAGE levels and hepatocyte and hepatic stellate cell (HSC) damage as well as the TAGE-RAGE-ROS axis in hepatocytes, HSC, and HCC cells. The "TAGE theory" will provide novel insights for future rese …
This review describes the relationships between intracellular TAGE levels and hepatocyte and hepatic stellate cell (HSC) damage as we …
Toxic AGEs (TAGE) theory: a new concept for preventing the development of diseases related to lifestyle.
Takeuchi M. Takeuchi M. Diabetol Metab Syndr. 2020 Nov 30;12(1):105. doi: 10.1186/s13098-020-00614-3. Diabetol Metab Syndr. 2020. PMID: 33292465 Free PMC article. Review.
TAGE leakage from cells affects the surrounding cells and increases serum TAGE levels, promoting the onset and/or development of lifestyle-related diseases (LSRD). Therefore, serum TAGE levels have potential as a novel biomarker for predicting the onset and/o …
TAGE leakage from cells affects the surrounding cells and increases serum TAGE levels, promoting the onset and/or development …
Involvement of the TAGE-RAGE system in non-alcoholic steatohepatitis: Novel treatment strategies.
Takeuchi M, Takino J, Sakasai-Sakai A, Takata T, Ueda T, Tsutsumi M, Hyogo H, Yamagishi S. Takeuchi M, et al. World J Hepatol. 2014 Dec 27;6(12):880-93. doi: 10.4254/wjh.v6.i12.880. World J Hepatol. 2014. PMID: 25544875 Free PMC article. Review.
All of these effects could facilitate the pathogenesis of hypertension, cancer, diabetic vascular complications, CVD, dementia, and NASH. Thus, inhibiting TAGE synthesis, preventing TAGE from binding to RAGE, and downregulating RAGE expression and/or the expression …
All of these effects could facilitate the pathogenesis of hypertension, cancer, diabetic vascular complications, CVD, dementia, and NASH. Th …
Serum Levels of Toxic AGEs (TAGE) May Be a Promising Novel Biomarker for the Onset/Progression of Lifestyle-Related Diseases.
Takeuchi M. Takeuchi M. Diagnostics (Basel). 2016 Jun 7;6(2):23. doi: 10.3390/diagnostics6020023. Diagnostics (Basel). 2016. PMID: 27338481 Free PMC article. Review.
TAGE also contribute to various diseases, such as cardiovascular disease; nonalcoholic steatohepatitis; cancer; Alzheimer's disease, and; infertility. ...We herein introduce the usefulness of serum TAGE levels as a biomarker for the prevention/early diagnosis of LSR …
TAGE also contribute to various diseases, such as cardiovascular disease; nonalcoholic steatohepatitis; cancer; Alzheimer's disease, …
TAGE (toxic AGEs) theory in diabetic complications.
Sato T, Iwaki M, Shimogaito N, Wu X, Yamagishi S, Takeuchi M. Sato T, et al. Curr Mol Med. 2006 May;6(3):351-8. doi: 10.2174/156652406776894536. Curr Mol Med. 2006. PMID: 16712480 Review.
Recent studies suggest that interaction of AGE-2 (predominantly structure of toxic AGEs; TAGE) with RAGE alters intracellular signaling, gene expression, release of pro-inflamatory molecules and production of reactive oxygen species (ROS) that contribute towards the pathol …
Recent studies suggest that interaction of AGE-2 (predominantly structure of toxic AGEs; TAGE) with RAGE alters intracellular signali …
Involvement of the toxic AGEs (TAGE)-RAGE system in the pathogenesis of diabetic vascular complications: a novel therapeutic strategy.
Takeuchi M, Takino J, Yamagishi S. Takeuchi M, et al. Curr Drug Targets. 2010 Nov;11(11):1468-82. doi: 10.2174/1389450111009011468. Curr Drug Targets. 2010. PMID: 20583971 Review.
Recently, we demonstrated that glyceraldehyde-derived AGEs (Glycer-AGEs), the predominant components of toxic AGEs (TAGE), play an important role in the pathogenesis of angiopathy in diabetic patients. ...Therefore, the inhibition of TAGE formation, blockade of T …
Recently, we demonstrated that glyceraldehyde-derived AGEs (Glycer-AGEs), the predominant components of toxic AGEs (TAGE), play an im …
931 results