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Page 1
Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease.
Eikelboom JW, Connolly SJ, Bosch J, Dagenais GR, Hart RG, Shestakovska O, Diaz R, Alings M, Lonn EM, Anand SS, Widimsky P, Hori M, Avezum A, Piegas LS, Branch KRH, Probstfield J, Bhatt DL, Zhu J, Liang Y, Maggioni AP, Lopez-Jaramillo P, O'Donnell M, Kakkar AK, Fox KAA, Parkhomenko AN, Ertl G, Störk S, Keltai M, Ryden L, Pogosova N, Dans AL, Lanas F, Commerford PJ, Torp-Pedersen C, Guzik TJ, Verhamme PB, Vinereanu D, Kim JH, Tonkin AM, Lewis BS, Felix C, Yusoff K, Steg PG, Metsarinne KP, Cook Bruns N, Misselwitz F, Chen E, Leong D, Yusuf S; COMPASS Investigators. Eikelboom JW, et al. N Engl J Med. 2017 Oct 5;377(14):1319-1330. doi: 10.1056/NEJMoa1709118. Epub 2017 Aug 27. N Engl J Med. 2017. PMID: 28844192 Free article. Clinical Trial.
Intra- and interregional coregulation of opioid genes: broken symmetry in spinal circuits.
Kononenko O, Galatenko V, Andersson M, Bazov I, Watanabe H, Zhou XW, Iatsyshyna A, Mityakina I, Yakovleva T, Sarkisyan D, Ponomarev I, Krishtal O, Marklund N, Tonevitsky A, Adkins DL, Bakalkin G. Kononenko O, et al. FASEB J. 2017 May;31(5):1953-1963. doi: 10.1096/fj.201601039R. Epub 2017 Jan 25. FASEB J. 2017. PMID: 28122917 Free PMC article.
The striking feature of this system is its asymmetric coexpression patterns, which suggest side-specific regulation of selective neural circuits by opioid neurohormones.-Kononenko, O., Galatenko, V., Andersson, M., Bazov, I., Watanabe, H., Zhou, X. W., Iatsyshyna, A., Mity …
The striking feature of this system is its asymmetric coexpression patterns, which suggest side-specific regulation of selective neural circ …
Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses.
Needham EJ, Ren AL, Digby RJ, Norton EJ, Ebrahimi S, Outtrim JG, Chatfield DA, Manktelow AE, Leibowitz MM, Newcombe VFJ, Doffinger R, Barcenas-Morales G, Fonseca C, Taussig MJ, Burnstein RM, Samanta RJ, Dunai C, Sithole N, Ashton NJ, Zetterberg H, Gisslén M, Edén A, Marklund E, Openshaw PJM, Dunning J, Griffiths MJ, Cavanagh J, Breen G, Irani SR, Elmer A, Kingston N, Summers C, Bradley JR, Taams LS, Michael BD, Bullmore ET, Smith KGC, Lyons PA, Coles AJ, Menon DK; Cambridge NeuroCOVID Group; CITIID-NIHR COVID-19 BioResource Collaboration; Cambridge NIHR Clinical Research Facility. Needham EJ, et al. Brain. 2022 Nov 21;145(11):4097-4107. doi: 10.1093/brain/awac321. Brain. 2022. PMID: 36065116 Free PMC article.
Quantitative Systems Pharmacology: An Exemplar Model-Building Workflow With Applications in Cardiovascular, Metabolic, and Oncology Drug Development.
Helmlinger G, Sokolov V, Peskov K, Hallow KM, Kosinsky Y, Voronova V, Chu L, Yakovleva T, Azarov I, Kaschek D, Dolgun A, Schmidt H, Boulton DW, Penland RC. Helmlinger G, et al. CPT Pharmacometrics Syst Pharmacol. 2019 Jun;8(6):380-395. doi: 10.1002/psp4.12426. Epub 2019 Jun 11. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 31087533 Free PMC article. Review.
Tracking SARS-COV-2 variants using Nanopore sequencing in Ukraine in 2021.
Yakovleva A, Kovalenko G, Redlinger M, Liulchuk MG, Bortz E, Zadorozhna VI, Scherbinska AM, Wertheim JO, Goodfellow I, Meredith L, Vasylyeva TI. Yakovleva A, et al. Sci Rep. 2022 Sep 21;12(1):15749. doi: 10.1038/s41598-022-19414-y. Sci Rep. 2022. PMID: 36131001 Free PMC article.
Deletions of the cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) genes, involved in the control of hydrogen sulfide biosynthesis, significantly affect lifespan and fitness components of Drosophila melanogaster.
Shaposhnikov MV, Zakluta AS, Zemskaya NV, Guvatova ZG, Shilova VY, Yakovleva DV, Gorbunova AA, Koval LA, Ulyasheva NS, Evgen'ev MB, Zatsepina OG, Moskalev AA. Shaposhnikov MV, et al. Mech Ageing Dev. 2022 Apr;203:111656. doi: 10.1016/j.mad.2022.111656. Epub 2022 Mar 2. Mech Ageing Dev. 2022. PMID: 35247392
Differentiating the Sodium-Glucose Cotransporter 1 Inhibition Capacity of Canagliflozin vs. Dapagliflozin and Empagliflozin Using Quantitative Systems Pharmacology Modeling.
Sokolov V, Yakovleva T, Chu L, Tang W, Greasley PJ, Johansson S, Peskov K, Helmlinger G, Boulton DW, Penland RC. Sokolov V, et al. CPT Pharmacometrics Syst Pharmacol. 2020 Apr;9(4):222-229. doi: 10.1002/psp4.12498. Epub 2020 Mar 6. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 32064793 Free PMC article.
Chronic optogenetic stimulation of Bergman glia leads to dysfunction of EAAT1 and Purkinje cell death, mimicking the events caused by expression of pathogenic ataxin-1.
Shuvaev AN, Belozor OS, Mozhei O, Yakovleva DA, Potapenko IV, Shuvaev AN, Smolnikova MV, Salmin VV, Salmina AB, Hirai H, Teschemacher AG, Kasparov S. Shuvaev AN, et al. Neurobiol Dis. 2021 Jul;154:105340. doi: 10.1016/j.nbd.2021.105340. Epub 2021 Mar 19. Neurobiol Dis. 2021. PMID: 33753288 Free article.
Neurotherapeutic activity of the recombinant heat shock protein Hsp70 in a model of focal cerebral ischemia in rats.
Shevtsov MA, Nikolaev BP, Yakovleva LY, Dobrodumov AV, Dayneko AS, Shmonin AA, Vlasov TD, Melnikova EV, Vilisov AD, Guzhova IV, Ischenko AM, Mikhrina AL, Galibin OV, Yakovenko IV, Margulis BA. Shevtsov MA, et al. Drug Des Devel Ther. 2014 May 28;8:639-50. doi: 10.2147/DDDT.S62024. eCollection 2014. Drug Des Devel Ther. 2014. PMID: 24920887 Free PMC article.
Rats were then kept alive for 72 hours. The ischemic region was analyzed using a high-field 11 T MRI scanner. Administration of the Hsp70 decreased the infarction zone in a dose-dependent manner with an optimal (threefold) therapeutic response at 5 mg/kg. Long-term treatme …
Rats were then kept alive for 72 hours. The ischemic region was analyzed using a high-field 11 T MRI scanner. Administration of the H …
22 results